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Showing 1601 to 1625 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2074	1635: Increase, DNA strand breaks	1365: Increase, Apoptosis	Apr 6, 2020	Jul 3, 2026	None
2587	1635: Increase, DNA strand breaks	1444: Increase, Follicular atresia	Mar 1, 2022	Mar 1, 2022	1 AOP 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia
2589	1635: Increase, DNA strand breaks	1775: Increase, Oocyte apoptosis	Mar 1, 2022	Mar 1, 2022	1 AOP 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis
2841	1635: Increase, DNA strand breaks	2098: Abnormal Neural Remodeling	Jan 25, 2023	Jul 29, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
2856	1635: Increase, DNA strand breaks	2066: Altered Signaling	Mar 10, 2023	Mar 21, 2023	None
3315	1635: Increase, DNA strand breaks	2244: Altered Stress Response Signaling	Jul 24, 2024	Aug 26, 2024	2 AOPs 470: Deposition of energy leads to abnormal vascular remodeling 483: Deposition of Energy Leading to Learning and Memory Impairment
3480	1635: Increase, DNA strand breaks	1505: Cell cycle disruption	Jan 20, 2025	Jan 20, 2025	2 AOPs 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption
3593	1635: Increase, DNA strand breaks	1281: Increased, DNA Damage-Repair	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
3797	1635: Increase, DNA strand breaks	55: Cell injury/death	May 12, 2026	Jun 23, 2026	1 AOP 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death
3801	1635: Increase, DNA strand breaks	1262: Apoptosis	Jul 3, 2026	Jul 3, 2026	1 AOP 322: Alkylation of DNA leading to decreased sperm count
1883	1619: Increase, DNMT inhibition	1620: Increase, DNA hypomethylation	Apr 22, 2019	Apr 22, 2019	None
2101	1619: Increase, DNMT inhibition	1773: Decrease, Global DNA methylation	Apr 30, 2020	Apr 30, 2020	4 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
3098	1619: Increase, DNMT inhibition	1461: Increase, DSB	Nov 16, 2023	Nov 16, 2023	1 AOP 338: DNA methyltransferase inhibition leading to population decline (3)
3305	1619: Increase, DNMT inhibition	1457: EMT	Jul 18, 2024	Jul 18, 2024	1 AOP 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT
1993	1697: Increase, DNMT expression	1698: Increase, hypermethylation of the promotor region of GnRHR	Oct 30, 2019	Oct 30, 2019	1 AOP 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
1884	1620: Increase, DNA hypomethylation	1621: Increase, Gene expression	Apr 22, 2019	Apr 22, 2019	None
1887	1620: Increase, DNA hypomethylation	1622: Decrease, Transgenerational DNA methylation	Apr 22, 2019	Apr 22, 2019	None
1635	1461: Increase, DSB	1253: MLL translocation	Aug 2, 2017	Aug 1, 2022	1 AOP 202: Inhibitor binding to topoisomerase II leading to infant leukaemia
3096	1461: Increase, DSB	1365: Increase, Apoptosis	Nov 16, 2023	Nov 16, 2023	1 AOP 330: Excessive reactive oxygen species production leading to mortality (4)
3099	1461: Increase, DSB	1774: Increase, Casp transcription	Nov 16, 2023	Nov 16, 2023	1 AOP 338: DNA methyltransferase inhibition leading to population decline (3)
1301	1194: Increase, DNA Damage	1239: Altered, Gene Expression	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1468	1194: Increase, DNA Damage	1365: Increase, Apoptosis	Apr 15, 2017	Apr 15, 2017	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
1897	1194: Increase, DNA Damage	185: Increase, Mutations	May 7, 2019	May 8, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
1898	1194: Increase, DNA Damage	1492: Tissue resident cell activation	May 7, 2019	May 10, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
1899	1194: Increase, DNA Damage	1553: Increase mutations	May 7, 2019	May 7, 2019	None

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