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Showing 3051 to 3075 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1866	1512: Unfolded Protein Response	1262: Apoptosis	Mar 6, 2019	Mar 6, 2019	1 AOP 285: Inhibition of N-linked glycosylation leads to liver injury
2712	1512: Unfolded Protein Response	1825: Increase, Cell death	Jul 25, 2022	Jul 25, 2022	None
3041	1512: Unfolded Protein Response	2188: Caspase activation	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
1161	1114: Unknown, MIE	1115: Increase, ROS	Nov 29, 2016	Dec 3, 2016	1 AOP 186: unknown MIE leading to renal failure and mortality
2035	1114: Unknown, MIE	1113: Unknown,	Jan 26, 2020	Jan 26, 2020	None
2036	1114: Unknown, MIE	294: N/A, Unknown	Jan 26, 2020	Jan 26, 2020	None
517	470: Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)	458: Increased, De Novo FA synthesis	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis
66	54: Up Regulation, CD36	115: Increase, FA influx	Nov 29, 2016	Mar 27, 2024	2 AOPs 34: LXR activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis
501	54: Up Regulation, CD36	465: Increased, FA Influx	Nov 29, 2016	Dec 3, 2016	3 AOPs 57: AhR activation leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis
2262	54: Up Regulation, CD36	460: Increased, Fatty acid uptake	Jan 15, 2021	Jan 15, 2021	None
96	80: Up Regulation, CYP1A1	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	None
104	84: Up Regulation, CYP1B1	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Nov 29, 2016	Dec 3, 2016	None
492	463: Up Regulation, FAS	458: Increased, De Novo FA synthesis	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis
507	466: Up Regulation, LDLR (low density lipoprotein receptor)	467: Increased, LDL uptake	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
493	462: Up Regulation, SCD-1	454: Increased, Triglyceride formation	Nov 29, 2016	Dec 3, 2016	2 AOPs 58: NR1I3 (CAR) suppression leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
1657	462: Up Regulation, SCD-1	291: Accumulation, Triglyceride	Aug 31, 2017	Aug 31, 2017	1 AOP 57: AhR activation leading to hepatic steatosis
1371	1284: Up Regulation, SREBF2	1285: Up Regulation, Unsaturated fatty acid	Feb 15, 2017	Feb 15, 2017	1 AOP 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
303	276: Up Regulation, TGFbeta1 expression	68: Increase, Collagen accumulation	Nov 29, 2016	Dec 3, 2016	None
304	276: Up Regulation, TGFbeta1 expression	265: Increase, HSC activation	Nov 29, 2016	Nov 29, 2016	None
1372	1285: Up Regulation, Unsaturated fatty acid	1289: Perturbation of cholesterol	Feb 15, 2017	Feb 15, 2017	1 AOP 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
699	695: Upregulated, Spindle assembly checkpoint protein Mad2-oocyte	696: Increased, Chromosome misseggregation	Nov 29, 2016	Dec 3, 2016	1 AOP 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
3583	2344: Upregulation, gadd45ba	2345: Activation, MAPK	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
3584	2344: Upregulation, gadd45ba	2346: Downregulation, PCNA	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
2084	1762: cell injury	795: Increase, Regenerative cell proliferation (urothelial cells)	Apr 21, 2020	Apr 21, 2020	1 AOP 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
3028	2178: Vascular barrier disruption	2161: Increase, Vascular disrupting effects	Aug 21, 2023	Aug 21, 2023	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects

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