Key Event Relationships (KERs)

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Showing 301 to 325 of 3081 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1479 1370: Activation, PTGS-2 1376: Increase, angiogenesis Apr 17, 2017 Apr 17, 2017
518 245: Activation, PXR/SXR 471: Inhibition, FoxA2 Nov 29, 2016 Dec 3, 2016
526 245: Activation, PXR/SXR 462: Up Regulation, SCD-1 Nov 29, 2016 Dec 3, 2016
529 245: Activation, PXR/SXR 54: Up Regulation, CD36 Nov 29, 2016 Dec 3, 2016
284 258: Activation, SCD-1 89: Synthesis, De Novo Fatty Acid (FA) Nov 29, 2016 Dec 3, 2016
1404 258: Activation, SCD-1 1306: Increase, De novo lipogenesis Apr 12, 2017 Apr 12, 2017 None
896 480: Activation, SHP 878: Inhibition, SREBP1c Nov 29, 2016 Dec 3, 2016
1409 480: Activation, SHP 227: Activation, PPARĪ± Apr 12, 2017 Apr 12, 2017 None
1412 480: Activation, SHP 1307: Inhibition, LXR Apr 12, 2017 Apr 12, 2017 None
1414 480: Activation, SHP 1308: Inhibition, LRH-1 Apr 12, 2017 Apr 12, 2017 None
987 924: Activation, Sp1 962: Increase, Mucin production Nov 29, 2016 Aug 11, 2021 None
482 457: Activation, SREBF1 458: Increased, De Novo FA synthesis Nov 29, 2016 Dec 3, 2016 None
489 457: Activation, SREBF1 462: Up Regulation, SCD-1 Nov 29, 2016 Dec 3, 2016
1662 457: Activation, SREBF1 459: Increase, Liver steatosis Aug 31, 2017 Aug 31, 2017
1397 1301: Activation, SREBP-1 1304: Activation, FXR Apr 12, 2017 Apr 12, 2017 None
1403 1301: Activation, SREBP-1 258: Activation, SCD-1 Apr 12, 2017 Apr 12, 2017 None
294 264: Activation, SREBP-1c 89: Synthesis, De Novo Fatty Acid (FA) Nov 29, 2016 Dec 3, 2016
1868 1606: Activation, Stellate cell 1549: Liver Injury Mar 6, 2019 Mar 6, 2019
3733 1606: Activation, Stellate cell 68: Increase, Collagen accumulation Feb 11, 2026 Feb 11, 2026 None
1016 978: Activation, Suppression of NFAT activation and hindrance of nuclear localization 979: Interference, nuclear localization of NFAT Nov 29, 2016 Dec 3, 2016 None
1370 1283: Activation, TGF-beta pathway 1277: Reproductive failure Feb 15, 2017 Feb 15, 2017
2153 1283: Activation, TGF-beta pathway 1457: EMT Jul 9, 2020 Jul 9, 2020
1832 1576: Activation, Tissue resident cells (Kuppfer cells) 1579: Increase, proinflammatory mediators (TNFalpha) Jan 7, 2019 Jan 7, 2019
1652 1469: TGFbeta pathway activation 1456: Differentiation of fibroblasts Aug 16, 2017 Aug 16, 2017
1653 1469: TGFbeta pathway activation 1457: EMT Aug 16, 2017 Aug 16, 2017