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All KERs

Showing 1826 to 1850 of 3119 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2839	2097: Increase, Pro-Inflammatory Mediators	341: Impairment, Learning and memory	Jan 25, 2023	Jul 26, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
2339	1864: Increase, Programmed cell death	1479: Decrease, Leaf development	Apr 11, 2021	Apr 11, 2021	None
2553	1864: Increase, Programmed cell death	1863: Decrease, Reproduction	Jan 21, 2022	Jan 21, 2022	1 AOP 388: Deposition of ionising energy leading to population decline via programmed cell death
944	923: Increased goblet cell proliferation	921: Goblet cell hyperplasia	Nov 29, 2016	Aug 27, 2021	None
2090	1767: Increase, Protein oxidation	1768: Increase, Abnormal osmoregulation	Apr 30, 2020	Apr 30, 2020	1 AOP 327: Excessive reactive oxygen species production leading to mortality (1)
2223	1767: Increase, Protein oxidation	1825: Increase, Cell death	Dec 4, 2020	Dec 4, 2020	None
3361	1767: Increase, Protein oxidation	55: Cell injury/death	Oct 8, 2024	Oct 8, 2024	None
3568	1767: Increase, Protein oxidation	1994: Ferroptosis	Aug 13, 2025	Aug 13, 2025	None
3633	1767: Increase, Protein oxidation	1446: Decrease, Coupling of OXPHOS	Sep 8, 2025	Sep 8, 2025	1 AOP 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death
3634	1767: Increase, Protein oxidation	179: Decrease, Fatty acid β-oxidation	Sep 8, 2025	Sep 8, 2025	3 AOPs 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation
3636	1767: Increase, Protein oxidation	1505: Cell cycle, disrupted	Sep 8, 2025	Sep 8, 2025	1 AOP 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption
2802	2077: behavioral change leading to possible reduced feeding opportunity	1521: Decrease, Growth	Nov 16, 2022	Nov 16, 2022	1 AOP 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
272	246: Increase, RBC congestion in liver	173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
1696	1115: Increase, ROS	1491: increased, oncotic necrosis	Nov 14, 2017	Nov 14, 2017	1 AOP 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
1965	1115: Increase, ROS	1669: Increased, DNA damage and mutation	Jul 3, 2019	Jul 3, 2019	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma
2009	1115: Increase, ROS	1392: Increase, Oxidative Stress	Dec 3, 2019	Aug 2, 2024	25 AOPs 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 521: Essential element imbalance leads to reproductive failure via oxidative stress 186: unknown MIE leading to renal failure and mortality 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 462: Activation of reactive oxygen species leading the atherosclerosis 396: Deposition of ionizing energy leads to population decline via impaired meiosis 26: Calcium-mediated neuronal ROS production and energy imbalance 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. 324: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death 325: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell growth 326: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell proliferation 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 332: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell growth 333: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation 595: Emerging OPFRS reproductive outcome pathway 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 472: DNA adduct formation leading to kidney failure
2033	1115: Increase, ROS	1648: β-catenin activation	Jan 19, 2020	Jan 19, 2020	None
2320	1115: Increase, ROS	1172: Increased activation, Nuclear factor kappa B (NF-kB)	Apr 10, 2021	Apr 10, 2021	2 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis
2324	1115: Increase, ROS	1501: Increase, ECM deposition	Apr 10, 2021	Apr 10, 2021	1 AOP 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
2328	1115: Increase, ROS	1855: Increased Sodium-sensitive hypertension	Apr 10, 2021	Apr 10, 2021	1 AOP 384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
2460	1115: Increase, ROS	1445: Increase, LPO	Aug 5, 2021	Apr 11, 2024	4 AOPs 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 521: Essential element imbalance leads to reproductive failure via oxidative stress 329: Excessive reactive oxygen species production leading to mortality (3)
2549	1115: Increase, ROS	1861: D1 protein deactivation	Jan 21, 2022	Jan 21, 2022	1 AOP 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
2550	1115: Increase, ROS	1770: Decrease, MMP	Jan 21, 2022	Jan 21, 2022	2 AOPs 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 328: Excessive reactive oxygen species production leading to mortality (2)
2594	1115: Increase, ROS	68: Increase, Collagen accumulation	Mar 3, 2022	Mar 3, 2022	None
2660	1115: Increase, ROS	2006: Secondary genotoxicity	May 25, 2022	May 25, 2022	1 AOP 451: Interaction with lung resident cell membrane components leads to lung cancer

Key Event Relationships (KERs)

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