Prototypical Stressors

Showing 501 to 525 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

137	Flutamide	Flutamide, CAS-RN: 13311-84-7, DTXSID7032004	5 AOPs 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring 619: Androgen receptor antagonism leads to delayed preputial separation via reduced fibroblast growth factor in genital-tubercle tissues
558	Flusilazole	Flusilazole, CAS-RN: 85509-19-9, DTXSID3024235	None
202	Fluoxetine		3 AOPs 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
231	Fluoroquinolones:		555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
870	Fluorene	Fluorene, CAS-RN: 86-73-7, DTXSID8024105	2 AOPs 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
871	Fluoranthene	Fluoranthene, CAS-RN: 206-44-0, DTXSID3024104	2 AOPs 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
190	flunixin meglumine	Flunixin meglumine, CAS-RN: 42461-84-7, DTXSID1045584	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
290	Fluconazole	Fluconazole, CAS-RN: 86386-73-4, DTXSID3020627	None
790	Flecainide		553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
111	Fipronil	Fipronil, CAS-RN: 120068-37-3, DTXSID4034609	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
441	finasteride, dutasteride, epristeride		289: Inhibition of 5α-reductase leading to impaired fecundity in female fish
145	Finasteride		3 AOPs 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring
571	ferric nitrilotriacetate		298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
311	Ferbam	Ferbam, CAS-RN: 14484-64-1, DTXSID8020624	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
418	Fenpyroximate	Fenpyroximate, CAS-RN: 134098-61-6, DTXSID7032557	3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
213	fenoxycarb	Fenoxycarb, CAS-RN: 72490-01-8, DTXSID7032393	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
211	Fenofibrate	Fenofibrate, CAS-RN: 49562-28-9, DTXSID2029874	2 AOPs 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
563	Fenitrothion	Fenitrothion, CAS-RN: 122-14-5, DTXSID4032613	None
384	Felodipine	Felodipine, CAS-RN: 72509-76-3, DTXSID4023042	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
26	Fadrozole	Fadrozole, CAS-RN: 102676-47-1, DTXSID5034141	3 AOPs 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation 25: Aromatase inhibition leading to reproductive dysfunction
598	Exemestane	Exemestane, CAS-RN: 107868-30-4, DTXSID5023037	346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
281	etoposide quinone		202: Inhibitor binding to topoisomerase II leading to infant leukaemia
223	Etoposide	Etoposide, CAS-RN: 33419-42-0, DTXSID5023035	202: Inhibitor binding to topoisomerase II leading to infant leukaemia
576	Etomidate	Etomidate, CAS-RN: 33125-97-2, DTXSID5023033	349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
56	Ethylenethiourea	Ethylene thiourea, CAS-RN: 96-45-7, DTXSID5020601	None