Prototypical Stressors

Showing 826 to 850 of 855 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

168	2-Imidazolidinimine, 1-[(6-chloro-3-pyridinyl)methyl]-N-nitro-, (2E)-		None
236	2-Chlorobenzalmalononitrile		196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
102	2-amino-4,6-dinitrotoluene	2-Amino-4,6-dinitrotoluene, CAS-RN: 35572-78-2, DTXSID6044068	None
5	17beta-Trenbolone	17beta-Trenbolone, CAS-RN: 10161-33-8, DTXSID0034192	3 AOPs 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 376: Androgen receptor agonism leading to male-biased sex ratio 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
4	17beta-Estradiol	17beta-Estradiol, CAS-RN: 50-28-2, DTXSID0020573	3 AOPs 314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
85	169590-42-5		None
73	131-55-5		None
640	11-Keto-testosterone	11-Ketotestosterone, CAS-RN: 564-35-2, DTXSID8036499	376: Androgen receptor agonism leading to male-biased sex ratio
372	10238-21-8		None
167	1',2'-dihydrorotenone	1',2'-Dihydrorotenone, CAS-RN: 6659-45-6, DTXSID5041227	None
535	1,5-dibenzoyloxymethyl-norcantharidin		154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
122	1,4-dichlorobenzene	1,4-Dichlorobenzene, CAS-RN: 106-46-7, DTXSID1020431	None
540	1,2:5,6-dibenzanthracene		None
670	1,2,5,6,9,10-Hexabromocyclododecane	1,2,5,6,9,10-Hexabromocyclododecane, CAS-RN: 3194-55-6, DTXSID4027527	None
162	1,2,4-triazole		153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
834	1,1'-Ethane-1,2-diylbis(pentabromobenzene)	1,1'-Ethane-1,2-diylbis(pentabromobenzene), CAS-RN: 84852-53-9, DTXSID2052732	3 AOPs 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
450	1-phenyl 2-thiourea		292: Inhibition of tyrosinase leads to decreased population in fish
3	1-Methylsulfonyloxyethane	Ethyl methanesulfonate, CAS-RN: 62-50-0, DTXSID6025309	None
782	1-Ethyl-1-nitrosourea	1-Ethyl-1-nitrosourea, CAS-RN: 759-73-9, DTXSID8020593	504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
84	1-Chloro-4-nitrobenzene	1-Chloro-4-nitrobenzene, CAS-RN: 100-00-5, DTXSID5020281	None
71	1-CHLORO-2,4- DINITROBENZENE	Glutathione, CAS-RN: 70-18-8, DTXSID6023101	None
296	>85 known Cyp2E1 substrates		220: Cyp2E1 Activation Leading to Liver Cancer
393	• Nefazodone, Amiodarone, Flutamide, Benzbromarone, Metformin, Tolcapone, Entacapone, Diclofenac		None
695	(R)-Talarozole	(R)-Talarozole, CAS-RN: 870093-23-5, DTXSID50236074	None
216	(7S)-Hydroprene	(7S)-Hydroprene, CAS-RN: 65733-18-8, DTXSID6035784	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline