Prototypical Stressors

Showing 201 to 225 of 855 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

171	Pyrethrins and Pyrethroids		3 AOPs 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 442: Binding to voltage gate sodium channels during development leads to cognitive impairment 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
541	psychosocial stress		403: combined unhealthy lifestyle factors leading to metabolic syndrome
445	Psammaplin A		2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
681	Prototypical stressor		211: Handbook development AOP
48	Propylthiouracil	6-Propyl-2-thiouracil, CAS-RN: 51-52-5, DTXSID5021209	5 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
582	Propylpyrazoletriol		None
139	Propylene oxide		None
155	Propyl Acetate	Propyl acetate, CAS-RN: 109-60-4, DTXSID6021901	None
287	Propiconazole	Propiconazole, CAS-RN: 60207-90-1, DTXSID8024280	None
505	Progesterone,estrogen,melatonin,Letrozole		309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
565	Procymidone	Procymidone, CAS-RN: 32809-16-8, DTXSID9033923	2 AOPs 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring
47	Prochloraz	Prochloraz, CAS-RN: 67747-09-5, DTXSID4024270	346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
705	Procainamide	Procainamide, CAS-RN: 51-06-9, DTXSID7023512	None
702	Probucol	Probucol, CAS-RN: 23288-49-5, DTXSID2045440	None
764	Preferred: Altered Gravity		None
487	Pralnacasan (VX-740) and Belnacasan (VX-765)		None
608	Pralnacasan (VX-740)		None
611	Pralnacasan (VX-740, HMR3480)		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
300	PPARalpha antagonists		2 AOPs 6: Antagonist binding to PPARα leading to body-weight loss 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
772	PPAR agonist		529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
455	Potassium bromate	Potassium bromate, CAS-RN: 7758-01-2, DTXSID6020195	296: Oxidative DNA damage leading to chromosomal aberrations and mutations
522	Porcupine		298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
242	Ponasterone A	Ponasterone A, CAS-RN: 13408-56-5, DTXSID0040595	2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
770	Polyvinyl chloride	Polyvinyl chloride, CAS-RN: 9002-86-2, DTXSID5025940	505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
593	Polyoxin D		360: Chitin synthase 1 inhibition leading to mortality