AOPs

OECD View API
Toggle for API info
The API endpoint defaults to 25 results per page, but you can adjust this by changing the per_page parameter in the URL.
Searches both title and fulltext content
Takes you to the requested AOP
Clear Search Terms Clears search terms and filters

Showing 1 to 25 of 581 AOPs

Clear Table Filters
ID Title Point of Contact License MIE AO OECD Status OECD Project
642 Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation Jung-Hwa Oh BY-SA 2421: Inhibition, Intestinal FXR 1489: Increase, Steatohepatitis
641 Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2418: Increased, phenotypic female-biased sex ratio
640 Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle John Frisch BY-SA 1065: Activation, estrogen receptor alpha 406: decreased, Fertility
639 Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2415: Precocious puberty
638 Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis Wei Mu BY-SA
637 Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2413: Increased, uterine weight
636 Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS) Shihori Tanabe All rights reserved 1115: Increase, Reactive oxygen species 2416: human amyotrophic lateral sclerosis (ALS)
635 Increased adrenal glucocorticoid production leading to MASLD progression (6) You Song BY-SA None None
634 Increased adrenal glucocorticoid production leading to MASLD progression (5) You Song BY-SA None None
633 Increased adrenal glucocorticoid production leading to MASLD progression (4) You Song BY-SA None None
632 Increased adrenal glucocorticoid production leading to MASLD progression (3) You Song BY-SA None None
631 Decreased thyroid hormone receptor beta transcriptional activity leading to MASLD progression via endoplasmic reticulum stress You Song BY-SA None None
630 Decreased 11β-Hydroxysteroid dehydrogenase type 2 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction You Song BY-SA 2409: Decrease, 11β-Hydroxysteroid dehydrogenase type 2 activity None Under Development
629 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
628 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
627 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
626 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
625 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
624 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
623 Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2306: Persistent vaginal cornification
622 Calcineurin inhibitor induced nephrotoxicity leading to kidney failure Kate Liang BY-SA None 759: Increased, Kidney Failure
621 NOX2 Driven Oxidative Stress-Induced α-Synuclein Radical Formation and Tau Nitration Leading to Neurodegeneration Tejasvi kumar Open for adoption None None
620 The Adverse Outcome Pathway to Deposition of Energy Leading to Female Decreased Fertility Jessica D'Urbano All rights reserved None None
619 Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues Travis Karschnik BY-SA 26: Antagonism, Androgen receptor 2401: Male preputial separation, failed/delayed
618 PPARgamma activation leads to a diminished vaccine response Léo SPORTES-MILOT BY-SA 1028: Activation of specific nuclear receptors, PPAR-gamma activation 2397: Diminished vaccine response