AOPs

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Showing 26 to 50 of 581 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
617 The adverse outcome pathway of vascular calcification Ruiyang Ding All rights reserved None None
616 organic UV filter and its Photoproducts reproductive toxicity pathways Nataraj Bojan All rights reserved 2391: Reduced fertility / fecundity
615 Suppression of Keap1 cysteine oxidation leading to liver inflammation Young Jun Kim All rights reserved 2385: Suppression of Keap1 cysteine oxidation 902: Inflammation, Liver
614 Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor You Song BY-SA 227: Activation, PPARα 947: Increase, Early Life Stage Mortality
613 Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production You Song BY-SA 227: Activation, PPARα 947: Increase, Early Life Stage Mortality
612 Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate You Song BY-SA 227: Activation, PPARα 947: Increase, Early Life Stage Mortality
611 Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes Donggon Yoo BY-SA 2379: Disruption of the regulatory function of dopamine signaling components. 2382: Increase, nerve spasm
610 Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function Nathalie Dierichs All rights reserved
609 Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release John Frisch BY-SA 1065: Activation, estrogen receptor alpha 1075: prolonged, estrus cycle
608 Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination Ki-Tae Kim All rights reserved None None
607 Per and Polyfluoro Alkylating Substances and Microbiota-Gut-Brain Axis Dhirendra Pratap Singh All rights reserved None None
606 Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1 You Song BY-SA 2374: Increase, Ecdysone receptor antagonism
605 Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination Ki-Tae Kim BY-SA 279: Thyroperoxidase, Inhibition
604 Binding of Alpha 1-Adrenergics to Antagonists Leading to Depression LUANA GOMES All rights reserved 2370: Antagonism binding, α1-Adrenoreceptor 1346: Increased, depression
603 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
602 Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
601 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
600 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
599 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
598 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
597 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell growth You Song BY-SA None None
596 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
595 Emerging OPFRS reproductive outcome pathway Shahena Perveen All rights reserved
594 Micro plastic effect on reproduction Shahena Perveen All rights reserved 1238: Activation of oxidative stress pathway 1277: Reproductive failure
593 Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons Stefan Schildknecht BY-SA 2362: Redox cycling of a chemical by mitochondria 896: Parkinsonian motor deficits