AOPs

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Showing 76 to 100 of 589 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
575 Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring Terje Svingen BY-SA None 1786: Nipple retention (NR), increased
574 Inhibition, cytochrome oxidase leads to Loss of olfactory function John Frisch BY-SA 1840: Inhibition, cytochrome oxidase 2317: Loss of olfactory function
573 Inhibition, cytochrome oxidase leads to Increased, pulmonary edema John Frisch BY-SA 1840: Inhibition, cytochrome oxidase 2316: Increased, pulmonary edema
572 BMP4 Suppression Disrupting Cytoskeletal Remodeling Leading to Neural Tube Closure Defects Job Berkhout BY-SA None None
571 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 2082: Hypospadias, increased
570 Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA None 2082: Hypospadias, increased
569 Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway Huimin Ma BY-SA 2309: Decreased DNA methylation of FAM50B/PTCHD3 2121: decreased, Intellectual Quotient
568 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding John Frisch BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1016: Inhibition, Feeding
567 Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition Li Xie BY-SA 2307: Binding of plastoquinone B (QB) within D1 protein of Photosystem II
566 Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation Martina Panzarea BY-SA None 2306: Persistent vaginal cornification
565 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha Martina Panzarea BY-SA 2250: 17β-Hydroxysteroid dehydrogenase 2, inhibition None
564 DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. lihua Yang BY-SA 1541: Mitochondrial Complex I inhibition
563 Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis Sapana Kushwaha BY-SA 18: Activation, AhR 2305: Premature ovarian Insufficiency
562 HCN Channel Inhibition leading to Arrhythmias Young Jun Kim BY-SA 2295: HCN Channel Inhibition 1106: Occurrence, cardiac arrhythmia
561 Aromatase induction leading to estrogen receptor alpha activation via increased estradiol Martina Panzarea BY-SA 2293: Aromatase, induction 1065: Activation, estrogen receptor alpha
560 Inhibition of Funny current (If) leading to Arrhythmias Young Jun Kim Open for adoption 2290: Inhibition of Funny current (If) 1106: Occurrence, cardiac arrhythmia
559 Inhibition of acetylcholinesterase (AChE) leading to arrhythmias Young Jun Kim BY-SA 12: Acetylcholinesterase (AchE) Inhibition 1106: Occurrence, cardiac arrhythmia
558 Phosphodiesterase inhibition leading to heart failure Young Jun Kim BY-SA 2288: Phosphodiesterase inhibition 1535: Heart failure
557 β2-Receptor agonist leading to Cardiomyopathy Young Jun Kim BY-SA 1039: Increased activity, beta-2 adrenergic receptor 2157: Abnormal Cardiac Structure and Function
556 Decreased Na/K ATPase activity leading to heart failure Young Jun Kim BY-SA 1562: Decreased Na/K ATPase activity 1535: Heart failure
555 Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure Young Jun Kim BY-SA 593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel 1535: Heart failure
554 β-adrenergic receptor agonists leading to arrhythmias. Young Jun Kim BY-SA 1038: Activation, beta-2 adrenergic receptor 1106: Occurrence, cardiac arrhythmia
553 Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure Young Jun Kim BY-SA 584: Inhibition, sodium channel 1535: Heart failure
552 Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) Young Jun Kim BY-SA 1529: Blockade, L-Type Calcium Channels 1535: Heart failure
551 Increased Muscarinic M2 Receptor leading to Arrhythmia Young Jun Kim Open for adoption 1602: Increased Muscarinic Acetylcholine Receptors 1106: Occurrence, cardiac arrhythmia