AOPs

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Showing 201 to 225 of 595 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
455 Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development Prarthana Shankar BY-SA 18: Activation, AhR WPHA/WNT Endorsed 1.27
454 PM2.5-related AOP frameworks on liver diseases Zhou Du BY-SA None None
453 Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population Ruiyang Ding BY-SA None None
452 Adverse outcome pathway of PM-induced respiratory toxicity li qing BY-SA 2007: Non-coding RNA expression profile alteration 2008: Chronic obstructive pulmonary disease
451 Interaction with lung resident cell membrane components leads to lung cancer Penny Nymark BY-SA 1495: Substance interaction with the lung resident cell membrane components 1670: Lung cancer
450 Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality SAROJ AMAR BY-SA 12: Acetylcholinesterase (AchE) Inhibition
449 Ceramide synthase inhibition leading to neural tube defects Lola Bajard BY-SA 2023: Inhibition of Ceramide Synthase 1561: Neural tube defects
448 ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality Ruiyang Ding BY-SA None None
447 Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways Yann GUEGUEN BY-SA None 759: Increased, Kidney Failure
446 PM-related Adverse outcome pathway frameworks on various systems Tianyu Li BY-SA None None
445 Estrogen Receptor Alpha Agonism leads to Impaired Reproduction John Hoang BY-SA 1065: Activation, estrogen receptor alpha 1991: Impaired, Reproduction
444 Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability Deborah Oughton BY-SA 360: Decrease, Population growth rate
443 DNA damage and mutations leading to Metastatic Breast Cancer Usha Adiga BY-SA 1669: Increased, DNA damage and mutation 1982: metastatic breast cancer Under Development 1.103
442 Binding to voltage gate sodium channels during development leads to cognitive impairment Iris Mangas BY-SA 1353: Binding to voltage-gated sodium channel 402: Cognitive function, decreased WPHA/WNT Endorsed 1.91
441 Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation Olivier ARMANT BY-SA 1686: Deposition of Energy 1978: Increase risk, microcephaly
440 Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia Kalyan Gayen BY-SA 1046: Suppression, Estrogen receptor (ER) activity Under Development 1.104
439 Activation of the AhR leading to metastatic breast cancer Louise Benoit BY-SA 18: Activation, AhR 1982: metastatic breast cancer Under Review 1.105
438 reactive oxygen species generation leading to increased cardiovascular morbidity and mortality Yu Yang BY-SA None None
437 Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity Baki Sadi BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 814: Occurrence, Kidney toxicity Under Development 1.99
436 Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries Gina Mennen BY-SA 1880: Decreased, ALDH1A (RALDH) enzyme activity 1970: transposition of the great arteries
435 Deposition of ionising energy leads to population decline via pollen abnormal Li Xie BY-SA 1686: Deposition of Energy
434 CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects Job Berkhout BY-SA None None
433 hERG channel blockade leading to sudden cardiac death Egemen Bilgin BY-SA 2099: hERG channel blockade 1964: Sudden cardiac death
432 Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia Dag Anders Brede BY-SA 1686: Deposition of Energy 1955: Acute Myeloid Leukemia
431 Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) Qi Wang BY-SA 1950: Increase, TNF 1953: Gestational diabetes mellitus