AOPs

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Showing 201 to 225 of 589 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
449 Ceramide synthase inhibition leading to neural tube defects Lola Bajard BY-SA 2023: Inhibition of Ceramide Synthase 1561: Neural tube defects
448 ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality Ruiyang Ding BY-SA None None
447 Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways Yann GUEGUEN BY-SA None 759: Increased, Kidney Failure
446 PM-related Adverse outcome pathway frameworks on various systems Tianyu Li BY-SA None None
445 Estrogen Receptor Alpha Agonism leads to Impaired Reproduction John Hoang BY-SA 1065: Activation, estrogen receptor alpha 1991: Impaired, Reproduction
444 Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability Deborah Oughton BY-SA 360: Decrease, Population growth rate
443 DNA damage and mutations leading to Metastatic Breast Cancer Usha Adiga BY-SA 1669: Increased, DNA damage and mutation 1982: metastatic breast cancer Under Development 1.103
442 Binding to voltage gate sodium channels during development leads to cognitive impairment Iris Mangas BY-SA 1353: Binding to voltage-gated sodium channel 402: Cognitive function, decreased WPHA/WNT Endorsed 1.91
441 Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation Olivier ARMANT BY-SA 1686: Deposition of Energy 1978: Increase risk, microcephaly
440 Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia Kalyan Gayen BY-SA 1046: Suppression, Estrogen receptor (ER) activity Under Development 1.104
439 Activation of the AhR leading to metastatic breast cancer Louise Benoit BY-SA 18: Activation, AhR 1982: metastatic breast cancer Under Review 1.105
438 reactive oxygen species generation leading to increased cardiovascular morbidity and mortality Yu Yang BY-SA None None
437 Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity Baki Sadi BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 814: Occurrence, Kidney toxicity Under Development 1.99
436 Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries Gina Mennen BY-SA 1880: Decreased, ALDH1A (RALDH) enzyme activity 1970: transposition of the great arteries
435 Deposition of ionising energy leads to population decline via pollen abnormal Li Xie BY-SA 1686: Deposition of Energy
434 CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects Job Berkhout BY-SA None None
433 hERG channel blockade leading to sudden cardiac death Egemen Bilgin BY-SA 2099: hERG channel blockade 1964: Sudden cardiac death
432 Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia Dag Anders Brede BY-SA 1686: Deposition of Energy 1955: Acute Myeloid Leukemia
431 Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) Qi Wang BY-SA 1950: Increase, TNF 1953: Gestational diabetes mellitus
430 Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation Sally Mayasich BY-SA 1739: Binding to ACE2 1939: Viral infection and host-to-host transmission, proliferated Under Development 1.96
429 A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants Erwin L Roggen BY-SA None 1941: Memory Loss
428 Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis Laure-Alix Clerbaux BY-SA 1739: Binding to ACE2 None Under Development 1.96
427 ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. Evangelos-Panagiotis Daskalopoulos BY-SA 1739: Binding to ACE2 1535: Heart failure
426 SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. Evangelos-Panagiotis Daskalopoulos BY-SA 1739: Binding to ACE2 1934: Myocardial Infarction
425 Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function