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Showing 451 to 475 of 574 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
511 The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects Yanhong Wei All rights reserved 1115: Increase, Reactive oxygen species 2161: Increase, Vascular disrupting effects
512 Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level Ana-Andreea Cioca All rights reserved None None
513 Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway John Frisch BY-SA 1115: Increase, Reactive oxygen species 885: Increase, Cancer
514 PLK1 Activation leading to hepatocyte apoptosis-associate liver injury via autophagy-mediated excessive COX6A1 degradation and impaired function of mitochondrial respiratory chain complex IV Hui Li All rights reserved None None
515 An overview of adverse outcome pathway linked between PM2.5 exposure and congenital heart defects Liang Chen All rights reserved None None
516 Na+ /K+ -ATPase inhibition leading to hypertension Michelle Angrish All rights reserved 1562: Decreased Na/K ATPase activity 952: Hypertension
517 Pregnane X Receptor (PXR) activation leads to liver steatosis John Frisch BY-SA 239: Activation, Pregnane-X receptor, NR1l2 459: Increase, Liver steatosis
518 Liver X Receptor (LXR) activation leads to liver steatosis John Frisch BY-SA 167: Activation, LXR 459: Increase, Liver steatosis
519 Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality Young Jun Kim Open for adoption 2282: Cardiac ion channels blockade 1929: Increased incidence of cardiovascular morbidity and mortality in the general population
520 Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory Diana Lupu Open for adoption 2201: Agonism, Retinoic acid receptor 341: Impairment, Learning and memory
521 Essential element imbalance leads to reproductive failure via oxidative stress Travis Karschnik BY-SA 2205: Increased, essential element imbalance 2147: Decreased, Viable Offspring
522 Estrogen antagonism leading to increased risk of autism-like behavior Kanglong Cui Open for adoption 112: Antagonism, Estrogen receptor 2209: autism-like behavior
523 Retinoic acid receptor agonism during neurodevelopment leading to microcephaly Diana Lupu Open for adoption 2201: Agonism, Retinoic acid receptor 1978: Increase risk, microcephaly
524 Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals Antonio Fernandez Dumont All rights reserved 2257: Celiac disease Under Review 1.98
525 Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory Ellen Fritsche Open for adoption 341: Impairment, Learning and memory
526 Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis John Frisch BY-SA None 1758: Impaired, Spermatogenesis
527 Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased John Frisch BY-SA None 2082: Hypospadias, increased
528 Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis John Frisch BY-SA None 1616: Malformation, cryptorchidism - maldescended testis
529 Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis Erik Mylroie BY-SA 2226: Stressor binding PPAR isoforms 459: Increase, Liver steatosis
530 Endocytotic lysosomal uptake leads to intestinal barrier disruption Laure-Alix Clerbaux All rights reserved 1539: Endocytotic lysosomal uptake 1931: Intestinal barrier, disruption
531 VEGFR inhibition leading to Keratinocyte differentiation-associate Hand-foot skin reaction Hui Li All rights reserved None None
532 Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function Diana Lupu Open for adoption 2201: Agonism, Retinoic acid receptor 2231: Locomotor function. Impaired
533 Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory Diana Lupu Open for adoption 2232: Antagonism, Retinoic acid receptors 341: Impairment, Learning and memory
534 Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress Xavier COUMOUL All rights reserved 2118: Succinate dehydrogenase, inhibited 885: Increase, Cancer
535 Binding and activation of GPER leading to learning and memory impairments Zedong Ouyang All rights reserved 2029: protein-coupled estrogen receptor 1 (GPER) activation 341: Impairment, Learning and memory