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Showing 526 to 550 of 574 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
587 Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits Barbara Viviani BY-SA 1542: Inhibition, Mitochondrial complex III 896: Parkinsonian motor deficits
588 Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits Barbara Viviani BY-SA 2118: Succinate dehydrogenase, inhibited 896: Parkinsonian motor deficits
589 Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits Barbara Viviani BY-SA 1543: Mitochondrial Complex IV inhibition 896: Parkinsonian motor deficits
590 Increase of intracellular copper leading to cuproptosis via interference with energy metabolism Sophie Scholz BY-SA 2339: Intracellular copper, increased 2343: Cuproptosis, increased
591 DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration lihua Yang BY-SA 1194: Increase, DNA damage 2019: Non-alcoholic fatty liver disease
592 DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis lihua Yang BY-SA
593 Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons Stefan Schildknecht BY-SA 2362: Redox cycling of a chemical by mitochondria 896: Parkinsonian motor deficits
594 Micro plastic effect on reproduction Shahena Perveen All rights reserved 1238: Activation of oxidative stress pathway 1277: Reproductive failure
595 Emerging OPFRS reproductive outcome pathway Shahena Perveen All rights reserved
596 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
597 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell growth You Song BY-SA None None
598 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
599 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
600 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
601 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
602 Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
603 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
604 Binding of Alpha 1-Adrenergics to Antagonists Leading to Depression LUANA GOMES All rights reserved 2370: Antagonism binding, α1-Adrenoreceptor 1346: Increased, depression
605 Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination Ki-Tae Kim BY-SA 279: Thyroperoxidase, Inhibition
606 Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1 You Song BY-SA 2374: Increase, Ecdysone receptor antagonism
607 Per and Polyfluoro Alkylating Substances and Microbiota-Gut-Brain Axis Dhirendra Pratap Singh All rights reserved None None
608 Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination Ki-Tae Kim All rights reserved None None
609 Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release John Frisch BY-SA 1065: Activation, estrogen receptor alpha 1075: prolonged, estrus cycle
610 Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function Nathalie Dierichs All rights reserved
611 Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes Donggon Yoo BY-SA 2379: Disruption of the regulatory function of dopamine signaling components. 2382: Increase, nerve spasm