AOP-Wiki

API

All Key Events

Showing 276 to 300 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

574	Increased, Appetite and hunger Short Name Increased, Appetite and hunger	1	Individual	Nov 29, 2016	Dec 3, 2016	81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
576	Increased, Viral susceptibility Short Name Increased, Viral susceptibility	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
577	impaired, Development Short Name impaired, Development	1	Individual	Nov 29, 2016	Dec 3, 2016	84: Suppression of immune system contributes to impaired development and leads to colony loss/failure
578	Decreased, Glucose oxidase enzyme activity Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
579	Decreased, Hydrogen peroxide production Short Name Decreased, Hydrogen peroxide production	1	Molecular	Nov 29, 2016	Sep 16, 2017	86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
580	Reduced, Antiseptic incorporated in food Short Name	0	Population	Nov 29, 2016	Dec 3, 2016	86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
583	impaired, Thoracic shivering Short Name impaired, Thoracic shivering	0	Individual	Nov 29, 2016	Dec 3, 2016	None
584	Inhibition, sodium channel Short Name Inhibition, sodium channel	2	Molecular	Nov 29, 2016	Sep 16, 2017	5 AOPs 91: Sodium channel inhibition leading to reduced survival 93: sodium channel inhibition leading to increased predation 94: Sodium channel inhibition leading to congenital malformations 197: Sodium channel (Nav1.1) inhibition leading to population decline 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
585	Decreased, Sodium conductance 1 Short Name Decreased, Sodium conductance 1	1	Cellular	Nov 29, 2016	Sep 16, 2017	4 AOPs 91: Sodium channel inhibition leading to reduced survival 93: sodium channel inhibition leading to increased predation 94: Sodium channel inhibition leading to congenital malformations 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
586	Reduced, swimming speed Short Name Reduced, swimming speed	1	Individual	Nov 29, 2016	Nov 29, 2016	3 AOPs 91: Sodium channel inhibition leading to reduced survival 93: sodium channel inhibition leading to increased predation 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
587	Reduced, feeding 1 Short Name Reduced, feeding 1	1	Individual	Nov 29, 2016	Nov 29, 2016	2 AOPs 91: Sodium channel inhibition leading to reduced survival 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
588	Increased, predation Short Name Increased, predation	1	Population	Nov 29, 2016	Dec 3, 2016	5 AOPs 93: sodium channel inhibition leading to increased predation 91: Sodium channel inhibition leading to reduced survival 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival 98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation 99: Histamine (H2) receptor antagonism leading to reduced survival
590	N/A, hypoxia Short Name N/A, hypoxia	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 94: Sodium channel inhibition leading to congenital malformations 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
591	Increased, amputations Short Name Increased, amputations	1	Individual	Nov 29, 2016	Dec 3, 2016	94: Sodium channel inhibition leading to congenital malformations
592	Reduced, survival Short Name Reduced, survival	1	Population	Nov 29, 2016	Dec 3, 2016	2 AOPs 91: Sodium channel inhibition leading to reduced survival 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
593	Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	2 AOPs 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
598	modulation, sodium channel Short Name modulation, sodium channel	1	Molecular	Nov 29, 2016	Sep 16, 2017	96: Axonal sodium channel modulation leading to acute mortality
599	prolonged, Depolarization of neuronal membrane Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	96: Axonal sodium channel modulation leading to acute mortality
600	Overactivation, Neuronotransmitter release Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	96: Axonal sodium channel modulation leading to acute mortality
601	Overactivation, muscle contraction Short Name Overactivation, muscle contraction	1	Tissue	Nov 29, 2016	Sep 16, 2017	96: Axonal sodium channel modulation leading to acute mortality
602	Increased, Ataxia, paralysis, or hyperactivity Short Name	3	Organ	Nov 29, 2016	Sep 16, 2017	2 AOPs 96: Axonal sodium channel modulation leading to acute mortality 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
613	Occurrence, Epileptic seizure Short Name Occurrence, Epileptic seizure	1	Individual	Nov 29, 2016	Apr 29, 2019	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
616	Occurrence, A paroxysmal depolarizing shift Short Name	1	Tissue	Nov 29, 2016	Apr 29, 2019	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
618	Decreased, Neuronal network function in adult brain Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	3 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 471: Neuron defect induced early behavioral change
619	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) Short Name	2	Molecular	Nov 29, 2016	Feb 24, 2025	6 AOPs 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding