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Showing 2526 to 2550 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3696	2388: photoproducts generate ROS	2363: Mito ROS dysfunction	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
1601	40: Mitochondrial ATP production, decreased	1366: Decrease, Oogenesis	Jun 29, 2017	Jun 29, 2017	None
1670	40: Mitochondrial ATP production, decreased	1478: Decrease, Leaf cell mitosis	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1682	40: Mitochondrial ATP production, decreased	709: Increase, Cytotoxicity (renal tubular cell)	Oct 25, 2017	Oct 25, 2017	1 AOP 258: Renal protein alkylation leading to kidney toxicity
1739	40: Mitochondrial ATP production, decreased	1521: Decrease, Growth	May 24, 2018	May 24, 2018	None
1750	40: Mitochondrial ATP production, decreased	1365: Increase, Apoptosis	Jun 12, 2018	Jun 12, 2018	None
1873	40: Mitochondrial ATP production, decreased	1607: Increase, Necrosis	Mar 19, 2019	Mar 19, 2019	None
2551	40: Mitochondrial ATP production, decreased	1863: Decrease, Reproduction	Jan 21, 2022	Jan 21, 2022	1 AOP 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction
2823	40: Mitochondrial ATP production, decreased	1532: Decrease, Cardiac contractility	Jan 5, 2023	Jan 5, 2023	1 AOP 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
3455	40: Mitochondrial ATP production, decreased	2300: Disruption, Glucolipid metabolism	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
3456	40: Mitochondrial ATP production, decreased	2151: Disruption, neurotransmitter release	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
3576	40: Mitochondrial ATP production, decreased	2343: Cuproptosis, increased	Aug 13, 2025	Aug 13, 2025	1 AOP 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
1780	1541: Mitochondrial Complex I inhibition	1545: Decrease in mitochondrial oxidative phosphorylation	Dec 19, 2018	Mar 7, 2019	None
3453	1541: Mitochondrial Complex I inhibition	2299: Altered, Redox Homeostasis	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
1782	1543: Mitochondrial Complex IV inhibition	1545: Decrease in mitochondrial oxidative phosphorylation	Dec 19, 2018	Mar 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
3555	1543: Mitochondrial Complex IV inhibition	177: Increase, Mitochondrial dysfunction	Aug 1, 2025	Aug 1, 2025	1 AOP 589: Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits
1783	1544: Mitochondrial Complex V inhibition	1545: Decrease in mitochondrial oxidative phosphorylation	Dec 19, 2018	Mar 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
2193	1816: Mitochondrial dysfunction EMPTY	1817: Apoptotic cell death	Nov 2, 2020	Nov 2, 2020	None
2195	1816: Mitochondrial dysfunction EMPTY	1815: Increase, ER stress	Nov 2, 2020	Nov 2, 2020	None
2499	1816: Mitochondrial dysfunction EMPTY	1392: Increase, Oxidative Stress	Oct 26, 2021	Oct 26, 2021	1 AOP 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
2932	1816: Mitochondrial dysfunction EMPTY	2144: Impaired insulin signaling	May 25, 2023	May 25, 2023	None
3043	1816: Mitochondrial dysfunction EMPTY	1585: Proteasomal dysfunction	Sep 14, 2023	Sep 14, 2023	None
188	178: Mitochondrial electron transport chain, disrupted	40: Mitochondrial ATP production, decreased	Nov 29, 2016	Dec 3, 2016	3 AOPs 26: Calcium-mediated neuronal ROS production and energy imbalance 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
3493	178: Mitochondrial electron transport chain, disrupted	1115: Increase, ROS	Feb 25, 2025	Feb 25, 2025	1 AOP 26: Calcium-mediated neuronal ROS production and energy imbalance
1942	1547: Mitochondrial Injury	889: Proteostasis, impaired	Jun 7, 2019	Jun 7, 2019	None

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