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Showing 2776 to 2800 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1447	1329: Reduce expression, BDNF	1330: Decreased, neuroplasticity	Apr 14, 2017	Apr 14, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 222: Mental stress to agitation 225: Serotonin transporter activation to agitation 224: Serotonin transporter activation to depression
3702	2398: Reduced antibody production	2397: Diminished vaccine response	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
2695	2024: Reduced complex sphingolipids	2025: Affected folate transporter	Jul 19, 2022	Jul 20, 2022	1 AOP 449: Ceramide synthase inhibition leading to neural tube defects
3127	2210: Reduced cortical thickness	2211: Microcephalus	Feb 2, 2024	Feb 2, 2024	None
3143	2210: Reduced cortical thickness	1978: Microcephaly	Mar 13, 2024	Mar 13, 2024	1 AOP 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
974	945: reduced dimerization, ARNT/HIF1-alpha	948: reduced production, VEGF	Nov 29, 2016	Mar 23, 2018	2 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 151: AhR activation leading to preeclampsia
1171	1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction	1136: Impaired recruitment , Population trajectory	Nov 29, 2016	Dec 3, 2016	1 AOP 187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
348	381: BDNF, Reduced	382: Aberrant, Dendritic morphology	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
353	381: BDNF, Reduced	55: Cell injury/death	Nov 29, 2016	Nov 29, 2016	2 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
354	381: BDNF, Reduced	383: Reduced, Presynaptic release of glutamate	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
445	381: BDNF, Reduced	427: Down Regulation, K-Cl co-transporter 2 (KCC2)	Nov 29, 2016	Dec 3, 2016	None
448	381: BDNF, Reduced	385: Synaptogenesis, Decreased	Nov 29, 2016	Apr 4, 2019	2 AOPs 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
870	381: BDNF, Reduced	851: GABAergic interneurons, Decreased	Nov 29, 2016	Jan 19, 2018	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
1507	381: BDNF, Reduced	341: Impairment, Learning and memory	May 10, 2017	May 29, 2018	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
3190	2223: Reduced number of oligodendrocytes	2107: Hypomyelination	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3441	2296: Reduced Pacemaker Activity in SA Node	2291: Bradycardia	Nov 24, 2024	Nov 24, 2024	1 AOP 562: HCN Channel Inhibition leading to Arrhythmias
975	948: reduced production, VEGF	110: Impairment, Endothelial network	Nov 29, 2016	Mar 23, 2018	1 AOP 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
2407	948: reduced production, VEGF	1891: abnormal, placental labyrinth vasculature morphology	May 31, 2021	May 31, 2021	1 AOP 151: AhR activation leading to preeclampsia
3682	948: reduced production, VEGF	28: Reduction, Angiogenesis	Oct 30, 2025	Oct 30, 2025	1 AOP 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
1975	1677: Reduced tidal volume	1678: Impaired oxygenation of the blood	Jul 3, 2019	Jul 3, 2019	None
2257	1677: Reduced tidal volume	1833: Impaired lung function	Jan 8, 2021	Jan 8, 2021	None
2367	1677: Reduced tidal volume	1250: Decreased lung function	Apr 27, 2021	Apr 27, 2021	1 AOP 302: Lung surfactant function inhibition leading to decreased lung function
674	674: Reduced, Ability to attract spawning mates	675: Reduced, Reproductive Success	Nov 29, 2016	Dec 3, 2016	2 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
1032	1007: Reduced, Anterior swim bladder inflation	1008: Reduced, Hearing	Nov 29, 2016	Dec 3, 2016	None
1034	1007: Reduced, Anterior swim bladder inflation	1005: Reduced, Swimming performance	Nov 29, 2016	Oct 7, 2022	3 AOPs 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation

Key Event Relationships (KERs)

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