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Showing 2801 to 2825 of 3119 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3247	2029: GPER activation	2233: Decreased, ERαβ heterodimers	Jun 19, 2024	Jun 19, 2024	1 AOP 535: Binding and activation of GPER leading to learning and memory impairments
905	889: Proteostasis, impaired	890: Degeneration of dopaminergic neurons of the nigrostriatal pathway	Nov 29, 2016	Oct 3, 2025	2 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
1943	889: Proteostasis, impaired	55: Cell injury/death	Jun 7, 2019	Jun 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
3579	889: Proteostasis, impaired	2343: Cuproptosis, increased	Aug 13, 2025	Aug 13, 2025	1 AOP 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
2679	2010: Pulmonary inflammation	2008: Chronic obstructive pulmonary disease	Jun 17, 2022	Jun 17, 2022	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity
3755	1967: Pyroptosis	2009: Activation, inflammation pathway	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
1848	1593: Radical generation	1597: DNA photo-adducts	Feb 4, 2019	Feb 4, 2019	None
1849	1593: Radical generation	1598: Protein photo-adducts	Feb 4, 2019	Feb 4, 2019	None
3629	2362: Redox cycling	2363: Mito ROS dysfunction	Sep 7, 2025	Oct 3, 2025	1 AOP 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
1447	1329: Reduce expression, BDNF	1330: Decreased, neuroplasticity	Apr 14, 2017	Apr 14, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 222: Mental stress to agitation 225: Serotonin transporter activation to agitation 224: Serotonin transporter activation to depression
3783	1757: Reduce, Sperm count	406: decreased, Fertility	Apr 24, 2026	Apr 24, 2026	1 AOP 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
3702	2398: Reduced antibody production	2397: Diminished vaccine response	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
2695	2024: Reduced complex sphingolipids	2025: Affected folate transporter	Jul 19, 2022	Jul 20, 2022	1 AOP 449: Ceramide synthase inhibition leading to neural tube defects
3127	2210: Reduced cortical thickness	2211: Microcephalus	Feb 2, 2024	Feb 2, 2024	None
3143	2210: Reduced cortical thickness	1978: Microcephaly	Mar 13, 2024	Mar 13, 2024	1 AOP 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
974	945: reduced dimerization, ARNT/HIF1-alpha	948: reduced production, VEGF	Nov 29, 2016	Mar 23, 2018	2 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 151: AhR activation leading to preeclampsia
1171	1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction	1136: Impaired recruitment , Population trajectory	Nov 29, 2016	Dec 3, 2016	1 AOP 187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
348	381: BDNF, Reduced	382: Aberrant, Dendritic morphology	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
353	381: BDNF, Reduced	55: Cell injury/death	Nov 29, 2016	Nov 29, 2016	2 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
354	381: BDNF, Reduced	383: Reduced, Presynaptic release of glutamate	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
445	381: BDNF, Reduced	427: Down Regulation, K-Cl co-transporter 2 (KCC2)	Nov 29, 2016	Dec 3, 2016	None
448	381: BDNF, Reduced	385: Synaptogenesis, Decreased	Nov 29, 2016	Apr 4, 2019	2 AOPs 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
870	381: BDNF, Reduced	851: GABAergic interneurons, Decreased	Nov 29, 2016	Jan 19, 2018	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
1507	381: BDNF, Reduced	341: Impairment, Learning and memory	May 10, 2017	May 29, 2018	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
3190	2223: Reduced number of oligodendrocytes	2107: Hypomyelination	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory

Key Event Relationships (KERs)

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