AOP-Wiki

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All KERs

Showing 601 to 625 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3541	2326: CTL cytotoxicity	1971: tumor growth	Jun 10, 2025	Jun 10, 2025	1 AOP 578: AhR activation leading to cancer progression via immunosuppression
3309	1508: CYP2E1 Activation	1392: Increase, Oxidative Stress	Jul 23, 2024	Jul 23, 2024	1 AOP 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
1493	1386: CYP7B activity, inhibition	1387: 7α-hydroxypregnenolone synthesis in the brain, decreased	May 2, 2017	May 17, 2017	2 AOPs 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
1494	1386: CYP7B activity, inhibition	1389: Locomotor activity, decreased	May 2, 2017	May 17, 2017	1 AOP 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
2440	1906: CFTR Function, Decreased	1907: ASL Height, Decreased	Jul 19, 2021	Sep 7, 2021	1 AOP 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
839	829: Damage, Lipid bilayer	833: Occurrence, Cytoplasmic vacuolization (hepatocyte)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
840	829: Damage, Lipid bilayer	835: Occurrence, Ballooning degeneration (hepatocyte)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
841	829: Damage, Lipid bilayer	836: Occurrence, Cytoplasmic vacuolization (Bile duct cell)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
842	829: Damage, Lipid bilayer	837: Occurrence, Cytoplasmic vacuolization (kupffer cell)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
277	250: Damaging, Red blood cells; hemolysis	161: Increase, Liver and splenic hemosiderosis	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
278	250: Damaging, Red blood cells; hemolysis	173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
279	250: Damaging, Red blood cells; hemolysis	246: Increase, RBC congestion in liver	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
3108	2200: decline, neural progenitor cells	1978: Microcephaly	Jan 10, 2024	Jan 10, 2024	1 AOP 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
1265	361: Decline, Population	1210: Alteration, Food-web structures	Nov 29, 2016	Dec 3, 2016	1 AOP 201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
3147	1258: Decompartmentalization	177: Increase, Mitochondrial dysfunction	Mar 13, 2024	Mar 13, 2024	1 AOP 205: AOP from chemical insult to cell death
1991	1696: Decrease of egg production and cummulative fecundity	679: Decline, Population trajectory	Oct 3, 2019	Oct 3, 2019	1 AOP 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
2389	1696: Decrease of egg production and cummulative fecundity	997: Decreased, Population size	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
3625	1696: Decrease of egg production and cummulative fecundity	1863: Decrease, Reproduction	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
871	851: GABAergic interneurons, Decreased	385: Synaptogenesis, Decreased	Nov 29, 2016	Jan 19, 2018	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
359	386: Neuronal network function, Decreased	341: Impairment, Learning and memory	Nov 29, 2016	Jul 15, 2022	6 AOPs 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
2411	386: Neuronal network function, Decreased	402: Cognitive function, decreased	Jun 24, 2021	Aug 27, 2021	1 AOP 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
2501	386: Neuronal network function, Decreased	1941: Memory Loss	Oct 26, 2021	Oct 26, 2021	1 AOP 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
2953	386: Neuronal network function, Decreased	2150: Neurological disorder	Jun 21, 2023	Jun 21, 2023	1 AOP 501: Excessive iron accumulation leading to neurological disorders
3123	386: Neuronal network function, Decreased	2209: autism-like behavior	Jan 25, 2024	Jan 25, 2024	1 AOP 522: Estrogen antagonism leading to increased risk of autism-like behavior
3666	386: Neuronal network function, Decreased	2108: Altered, white brain matter	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function

Key Event Relationships (KERs)

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