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Showing 676 to 700 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2547	1472: Decrease, ATP production	1863: Decrease, Reproduction	Jan 21, 2022	Jan 21, 2022	1 AOP 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
3559	1472: Decrease, ATP production	360: Decrease, Population growth rate	Aug 5, 2025	Feb 27, 2026	None
3772	1472: Decrease, ATP production	1521: Decrease, Growth	Apr 10, 2026	Apr 10, 2026	1 AOP 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
2176	1808: Decrease, ATP synthase activity	1771: Decrease, ATP pool	Nov 2, 2020	Nov 2, 2020	None
2344	1808: Decrease, ATP synthase activity	1479: Decrease, Leaf development	Apr 11, 2021	Apr 11, 2021	None
1757	1531: Decrease, Calcium binding to Troponin C	1532: Decrease, Cardiac contractility	Jun 19, 2018	Jun 19, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1756	1530: Decrease, Calcium currents	1531: Decrease, Calcium binding to Troponin C	Jun 19, 2018	Jun 19, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1760	1530: Decrease, Calcium currents	1536: Disruption, Intracellular calcium mobilization	Jun 21, 2018	Jun 21, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1758	1532: Decrease, Cardiac contractility	1533: Decrease, Cardiac ejection fraction	Jun 19, 2018	Jun 19, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
2824	1532: Decrease, Cardiac contractility	1535: Heart failure	Jan 5, 2023	Jan 5, 2023	3 AOPs 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure
3176	1532: Decrease, Cardiac contractility	2215: Decrease LV function	Apr 3, 2024	Apr 3, 2024	2 AOPs 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
1759	1533: Decrease, Cardiac ejection fraction	1535: Heart failure	Jun 19, 2018	Jun 19, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
3604	2327: Decrease, Cell growth	1521: Decrease, Growth	Aug 21, 2025	Aug 21, 2025	1 AOP 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth
2205	1821: Decrease, Cell proliferation	1521: Decrease, Growth	Nov 12, 2020	Jul 6, 2022	10 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation
2405	1821: Decrease, Cell proliferation	1878: Decreased, Eye size	May 28, 2021	Aug 7, 2021	1 AOP 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
2724	1821: Decrease, Cell proliferation	2041: Decrease, facial prominence outgrowth	Jul 28, 2022	Apr 2, 2025	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
3586	1821: Decrease, Cell proliferation	2348: Inhibition, Liver regeneration	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
2755	2060: Decrease, Chitin laminar organization	2062: Weak, Procuticle protection	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
1665	1473: Decrease, Chlorophyll synthesis	1474: Decrease, Light harvest capacity	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1347	1266: Decrease, Circulating CCAP	1267: Decrease, Ecdysis motor program activity	Feb 9, 2017	Feb 9, 2017	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
1000	988: Decrease, Circulating ETH	990: Increase, Incomplete ecdysis	Nov 29, 2016	Dec 3, 2016	None
1008	988: Decrease, Circulating ETH	993: Decrease, Abdominal muscle contraction	Nov 29, 2016	Dec 3, 2016	None
1346	988: Decrease, Circulating ETH	1266: Decrease, Circulating CCAP	Feb 9, 2017	Feb 9, 2017	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
2126	1690: Decrease, circulating testosterone levels	1613: Decrease, DHT level	May 11, 2020	Oct 19, 2023	1 AOP 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
2131	1690: Decrease, circulating testosterone levels	1614: Decrease, AR activation	May 11, 2020	Mar 20, 2026	4 AOPs 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring

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