AOP-Wiki

API

All KERs

Showing 901 to 925 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3174	2214: Decreased, INSL3	1615: Impaired inguinoscrotal phase	Mar 20, 2024	Dec 3, 2024	1 AOP 528: Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis
2867	2121: decreased, IQ	2122: increased, socio-economic burden	Apr 4, 2023	Apr 4, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
1554	1416: Decreased, intracellular chloride	1355: Activated, membrane depolarization	Jun 2, 2017	Jun 2, 2017	1 AOP 231: presynaptic neuron 2 repression to epilepsy
1432	1323: Decreased, intracellular serotonin	1324: Decreased, packaged serotonin	Apr 14, 2017	Apr 14, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1660	477: Decreased, Ketogenesis	327: Accumulation, Fatty acid	Aug 31, 2017	Aug 31, 2017	1 AOP 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
883	861: Decreased, Ketogenesis (production of ketone bodies)	862: Not Increased, Circulating Ketone Bodies	Nov 29, 2016	Jun 11, 2018	1 AOP 6: Antagonist binding to PPARα leading to body-weight loss
3469	531: Decreased, LH Surge	1695: Impaired ovulation	Jan 10, 2025	Jan 10, 2025	1 AOP 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
1109	1072: Decreased, LH Surge from anterior pituitary	1074: interruption, Ovulation	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1110	1072: Decreased, LH Surge from anterior pituitary	1075: prolonged, estrus cycle	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
651	635: Decreased, locomotion	588: Increased, predation	Nov 29, 2016	Dec 3, 2016	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
389	168: Decreased, Lymphocytes	323: Increased, Disease susceptibility	Nov 29, 2016	Dec 3, 2016	None
390	168: Decreased, Lymphocytes	403: Suppression, Immune system	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
2631	1988: Decreased, Maturation Inducing Steroids Surge by Granulosa cells	1989: Impaired, Oocyte maturation and ovulation	Apr 5, 2022	Apr 5, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
805	805: Decreased, mevalonate	807: Decreased, cholesterol	Nov 29, 2016	Dec 3, 2016	1 AOP 124: HMG-CoA reductase inhibition leading to decreased fertility
882	860: Decreased, Mitochondrial Fatty Acid Beta Oxidation	861: Decreased, Ketogenesis (production of ketone bodies)	Nov 29, 2016	Nov 29, 2016	None
2040	860: Decreased, Mitochondrial Fatty Acid Beta Oxidation	459: Increase, Liver steatosis	Feb 22, 2020	Feb 22, 2020	None
2264	860: Decreased, Mitochondrial Fatty Acid Beta Oxidation	291: Accumulation, Triglyceride	Jan 15, 2021	Jan 15, 2021	1 AOP 318: Glucocorticoid Receptor activation leading to hepatic steatosis
1787	1545: Decrease in mitochondrial oxidative phosphorylation	1547: Mitochondrial Injury	Dec 19, 2018	Mar 7, 2019	None
1956	1545: Decrease in mitochondrial oxidative phosphorylation	177: Increase, Mitochondrial dysfunction	Jun 15, 2019	Jun 15, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
3558	1545: Decrease in mitochondrial oxidative phosphorylation	1472: Decrease, ATP production	Aug 5, 2025	Feb 26, 2026	1 AOP 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
3719	1545: Decrease in mitochondrial oxidative phosphorylation	1771: Decrease, ATP pool	Feb 4, 2026	Feb 4, 2026	None
1535	1404: Decreased, mucosal blood flow	1405: Reduced, mucosal defense	Jun 2, 2017	Jun 2, 2017	1 AOP 227: NSAID induced PTGS1 inactivation to gastric ulcer
1538	1406: Decreased, mucous	1405: Reduced, mucosal defense	Jun 2, 2017	Jun 2, 2017	1 AOP 227: NSAID induced PTGS1 inactivation to gastric ulcer
3663	2105: Decreased, mbp expression in oligodendrocytes	2266: Demyelination, increased	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
634	618: Decreased, Neuronal network function in adult brain	341: Impairment, Learning and memory	Nov 29, 2016	Nov 29, 2016	1 AOP 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.

Key Event Relationships (KERs)

All KERs