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Showing 1551 to 1575 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1462	1361: Increase, GABA	1359: Activate, GABA-A receptor	Apr 14, 2017	Apr 14, 2017	1 AOP 215: Molecular events lead to epilepsy
1885	1621: Increase, Gene expression	328: Decrease, Fecundity	Apr 22, 2019	Apr 22, 2019	None
1234	1175: Increase, Genes involved in fatty acid oxidation	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	None
1240	1175: Increase, Genes involved in fatty acid oxidation	1173: Increase, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids	Nov 29, 2016	Dec 3, 2016	None
2226	1827: Increase, Global methylation	1365: Increase, Apoptosis	Dec 4, 2020	Dec 4, 2020	None
385	122: Increase, GR activation	145: Induction, IKB inhibitory protein	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
1451	122: Increase, GR activation	1335: Reduced, BDNF	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
2039	122: Increase, GR activation	860: Decreased, Mitochondrial Fatty Acid Beta Oxidation	Feb 22, 2020	Feb 22, 2020	None
2041	122: Increase, GR activation	231: Decreased, PPAR-alpha activation	Feb 22, 2020	Feb 22, 2020	None
2261	122: Increase, GR activation	54: Up Regulation, CD36	Jan 15, 2021	Jan 15, 2021	None
2266	122: Increase, GR activation	1834: Decrease, ACAD	Jan 15, 2021	Jan 15, 2021	1 AOP 318: Glucocorticoid Receptor activation leading to hepatic steatosis
3526	122: Increase, GR activation	2245: Altered cell differentiation signaling	Apr 18, 2025	Apr 18, 2025	1 AOP 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
3738	122: Increase, GR activation	2119: Increase, Insulin resistance	Feb 12, 2026	Feb 12, 2026	3 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress
3739	122: Increase, GR activation	450: Decrease, VLDL export capacity	Feb 12, 2026	Feb 12, 2026	None
3740	122: Increase, GR activation	1306: Increase, De novo lipogenesis	Feb 12, 2026	Feb 12, 2026	3 AOPs 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
2885	2133: Increase, Glucuronidation of T4	961: Increased, Clearance of thyroxine from serum	Apr 12, 2023	Apr 12, 2023	None
2794	2070: Increase, Glycolysis	2071: Decrease, Glucose pool	Nov 1, 2022	Nov 1, 2022	1 AOP 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion
2858	2117: Increase, goblet cell number	962: Increase, Mucin production	Mar 15, 2023	Mar 17, 2023	1 AOP 148: EGFR Activation Leading to Decreased Lung Function
3212	2137: Increase, Gonadotropins concentration in plasma	1690: Decrease, circulating testosterone levels	May 8, 2024	May 8, 2024	None
3716	2137: Increase, Gonadotropins concentration in plasma	2402: Increased, E2 production in ovaries	Jan 29, 2026	Feb 3, 2026	1 AOP 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release
3679	2383: Increase, Hemopericardium	947: Increase, Early Life Stage Mortality	Oct 30, 2025	Oct 30, 2025	3 AOPs 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
3742	2412: Increase, Hepatic intracellular active GC	122: Increase, GR activation	Feb 24, 2026	Feb 24, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
295	265: Increase, HSC activation	68: Increase, Collagen accumulation	Nov 29, 2016	Dec 5, 2018	8 AOPs 38: Protein Alkylation leading to Liver Fibrosis 144: Endocytic lysosomal uptake leading to liver fibrosis 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
2892	265: Increase, HSC activation	1501: Increase, ECM deposition	Apr 13, 2023	Jan 30, 2025	1 AOP 494: AhR activation leading to liver fibrosis
3217	265: Increase, HSC activation	459: Increase, Liver steatosis	May 14, 2024	May 14, 2024	None

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