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Showing 451 to 475 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2518	1935: Ang (1-7) levels reduced	1936: Degradation of Ang-II reduced	Oct 28, 2021	Oct 28, 2021	None
2519	1936: Degradation of Ang-II reduced	1741: Induced, Angiotensin (Ang) II accumulation	Oct 28, 2021	Oct 28, 2021	None
3645	2370: A1AR Antagonism	2371: Increased cortisol	Oct 1, 2025	Feb 26, 2026	1 AOP 604: Binding of Alpha 1-Adrenergics to Antagonists Leading to Depression
2123	26: Antagonism, Androgen receptor	1688: AGD, decreased	May 11, 2020	Aug 7, 2020	None
2130	26: Antagonism, Androgen receptor	1614: Decrease, AR activation	May 11, 2020	Mar 18, 2025	4 AOPs 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring 345: Androgen receptor (AR) antagonism leading to decreased fertility in females
2133	26: Antagonism, Androgen receptor	1786: nipple retention, increased	May 11, 2020	Sep 17, 2025	1 AOP 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring
2201	26: Antagonism, Androgen receptor	286: Altered, Transcription of genes by the AR	Nov 2, 2020	Feb 2, 2021	1 AOP 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
3397	26: Antagonism, Androgen receptor	310: Alteration, Wnt pathway	Nov 18, 2024	Nov 18, 2024	1 AOP 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
3617	26: Antagonism, Androgen receptor	2080: Impaired, blood testis barrier	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3705	26: Antagonism, Androgen receptor	2393: AR transcriptional activity in GT tissues, reduced	Dec 16, 2025	Feb 6, 2026	1 AOP 619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
129	112: Antagonism, Estrogen receptor	285: Reduction, Vitellogenin synthesis in liver	Nov 29, 2016	Nov 30, 2016	1 AOP 30: Estrogen receptor antagonism leading to reproductive dysfunction
2613	112: Antagonism, Estrogen receptor	1457: EMT	Mar 22, 2022	Aug 27, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
3120	112: Antagonism, Estrogen receptor	2207: inhibition, EKR1/2 signaling pathway	Jan 25, 2024	Jan 25, 2024	1 AOP 522: Estrogen antagonism leading to increased risk of autism-like behavior
1061	638: Antagonism, Histamine Receptor (H2)	633: Decrease, histaminergic neuron excitation	Nov 29, 2016	Dec 3, 2016	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
2720	2027: Antagonism Smoothened	2028: Decrease, GLI1/2 translocation	Jul 28, 2022	Jul 28, 2022	None
2734	2027: Antagonism Smoothened	2044: Decrease, SMO relocation	Aug 23, 2022	Apr 2, 2025	1 AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting
2894	2027: Antagonism Smoothened	2042: orofacial cleft	Apr 14, 2023	Apr 4, 2025	1 AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting
1947	1656: TR Antagnoism	756: Hippocampal gene expression, Altered	Jun 8, 2019	Jun 8, 2019	1 AOP 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
1948	1656: TR Antagnoism	402: Cognitive function, decreased	Jun 8, 2019	Jun 8, 2019	1 AOP 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
3186	1656: TR Antagnoism	2223: Reduced number of oligodendrocytes	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3193	1656: TR Antagnoism	2107: Hypomyelination	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3655	1656: TR Antagnoism	381: BDNF, Reduced	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
3660	1656: TR Antagnoism	1505: Cell cycle, disrupted	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
3661	1656: TR Antagnoism	2105: Decreased, mbp expression in oligodendrocytes	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1986	1691: Antagonism,LH receptor	1692: Reduction, Progesterone synthesis	Oct 3, 2019	Oct 3, 2019	1 AOP 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction

Key Event Relationships (KERs)

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