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All KERs

Showing 901 to 925 of 3119 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

829	819: Decreased, Glomerular filtration	814: Occurrence, Kidney toxicity	Nov 29, 2016	Dec 3, 2016	1 AOP 128: Kidney dysfunction by decreased thyroid hormone
576	578: Decreased, Glucose oxidase enzyme activity	579: Decreased, Hydrogen peroxide production	Nov 29, 2016	Dec 3, 2016	1 AOP 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
3596	2350: Decreased, Glycolysis	2351: Increased, OXPHOS	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
3465	530: Decreased, GnRH pulsatility/release	531: Decreased, LH Surge	Jan 3, 2025	Jan 3, 2025	1 AOP 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
3648	530: Decreased, GnRH pulsatility/release	1075: prolonged, estrus cycle	Oct 2, 2025	Jan 28, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
1108	1071: Decreased, GnRH pulsatility/release in hypothalamus	1072: Decreased, LH Surge from anterior pituitary	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
2629	1986: Decreased, Gonadotropins	1987: Decreased , Androgen and Progestin	Apr 5, 2022	Apr 5, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
3649	1986: Decreased, Gonadotropins	1075: prolonged, estrus cycle	Oct 2, 2025	Jan 28, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
154	140: Decreased, HSD17B10 expression	8: Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity	Nov 29, 2016	Dec 3, 2016	1 AOP 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
577	579: Decreased, Hydrogen peroxide production	580: Reduced, Antiseptic incorporated in food	Nov 29, 2016	Dec 3, 2016	1 AOP 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
3366	2268: Decreased, INSIG1 protein activity	2269: Increased, SREBP2 protein expression	Oct 22, 2024	Feb 10, 2025	2 AOPs 545: Activation, Pregnane-X receptor, NR1l2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis 548: Activation, Pregnane-X receptor, NR1l2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression
3174	2214: Decreased, INSL3	1615: Impaired inguinoscrotal phase	Mar 20, 2024	Dec 3, 2024	1 AOP 528: Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis
2867	2121: decreased, IQ	2122: increased, socio-economic burden	Apr 4, 2023	Apr 4, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
1554	1416: Decreased, intracellular chloride	1355: Activated, membrane depolarization	Jun 2, 2017	Jun 2, 2017	1 AOP 231: presynaptic neuron 2 repression to epilepsy
1432	1323: Decreased, intracellular serotonin	1324: Decreased, packaged serotonin	Apr 14, 2017	Apr 14, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1660	477: Decreased, Ketogenesis	327: Accumulation, Fatty acid	Aug 31, 2017	Aug 31, 2017	1 AOP 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
883	861: Decreased, Ketogenesis (production of ketone bodies)	862: Not Increased, Circulating Ketone Bodies	Nov 29, 2016	Jun 11, 2018	1 AOP 6: Antagonist binding to PPARα leading to body-weight loss
3469	531: Decreased, LH Surge	1695: Impaired ovulation	Jan 10, 2025	Jan 10, 2025	1 AOP 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
1109	1072: Decreased, LH Surge from anterior pituitary	1074: interruption, Ovulation	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1110	1072: Decreased, LH Surge from anterior pituitary	1075: prolonged, estrus cycle	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
651	635: Decreased, locomotion	588: Increased, predation	Nov 29, 2016	Dec 3, 2016	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
389	168: Decreased, Lymphocytes	323: Increased, Disease susceptibility	Nov 29, 2016	Dec 3, 2016	None
390	168: Decreased, Lymphocytes	403: Suppression, Immune system	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
2631	1988: Decreased, Maturation Inducing Steroids Surge by Granulosa cells	1989: Impaired, Oocyte maturation and ovulation	Apr 5, 2022	Apr 5, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
805	805: Decreased, mevalonate	807: Decreased, cholesterol	Nov 29, 2016	Dec 3, 2016	1 AOP 124: HMG-CoA reductase inhibition leading to decreased fertility

Key Event Relationships (KERs)

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