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Showing 1251 to 1275 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

158	142: Hyperplasia, Hyperplasia	334: Promotion, Hepatocelluar carcinoma	Nov 29, 2016	Dec 3, 2016	1 AOP 1: Uncharacterized liver damage leading to hepatocellular carcinoma
462	415: Hyperplasia, Leydig cell	406: decreased, Fertility	Nov 29, 2016	Dec 3, 2016	1 AOP 51: PPARα activation leading to impaired fertility in adult male rodents
1115	1078: Hyperplasia, Mammary gland	1080: Increased, latency period	Nov 29, 2016	Dec 3, 2016	1 AOP 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
1116	1078: Hyperplasia, Mammary gland	1079: Increased, Adenomas/carcinomas (mammary)	Nov 29, 2016	Dec 3, 2016	1 AOP 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
1093	1052: Hyperplasia, ovarian epithelium	1053: Promotion, ovarian adenomas	Nov 29, 2016	Dec 3, 2016	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1094	1051: Hyperplasia, ovarian stromal cells	1054: Promotion, ovarian granular cell tumors	Nov 29, 2016	Dec 3, 2016	1 AOP 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
755	763: hyperpolarisation, neuron	764: N/A, Ataxia, paralysis, or hyperactivity	Nov 29, 2016	Dec 3, 2016	1 AOP 113: Glutamate-gated chloride channel activation leading to acute mortality
1566	763: hyperpolarisation, neuron	1428: Analgesia	Jun 8, 2017	Jun 8, 2017	1 AOP 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening
1572	763: hyperpolarisation, neuron	1432: Anti-depressant Activity	Jun 23, 2017	Jun 23, 2017	1 AOP 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
1083	1043: Hypertrophy/hyperplasia, smooth muscle	1044: Promotion, mesovarian leiomyomas	Nov 29, 2016	Dec 3, 2016	1 AOP 164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
3191	2107: Hypomyelination	2108: Altered, white brain matter	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2197	1819: IFNγ signaling	1633: Increase in inflammation	Nov 2, 2020	Nov 2, 2020	1 AOP 362: Immune mediated hepatitis
2318	1856: Sodium inhibition, Sweet enhancement	1849: Impaired gustatory nerve	Apr 10, 2021	Apr 10, 2021	1 AOP 381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
2196	1818: Immune cell activation	1819: IFNγ signaling	Nov 2, 2020	Nov 2, 2020	1 AOP 362: Immune mediated hepatitis
3054	2180: immune mechanisms antagonized	2192: IAV production increased	Oct 3, 2023	Oct 3, 2023	1 AOP 506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
1278	1225: Leukocyte infiltration	1226: Respiratory irritability	Nov 29, 2016	Dec 3, 2016	None
1290	1225: Leukocyte infiltration	1237: Sensitization, Immune system	Nov 29, 2016	Dec 3, 2016	None
1923	1644: Impaired Ab production	986: Impairment of TDAR	May 23, 2019	Jun 25, 2019	None
1820	1568: Impaired antigen presentation	1569: Impaired T cell activation	Dec 25, 2018	Dec 25, 2018	None
3665	2378: Impaired axonal insulation	386: Neuronal network function, Decreased	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1835	1582: Impaired axonial transport	1583: Sensory axonal peripheral neuropathy	Jan 29, 2019	Jan 29, 2019	2 AOPs 279: Microtubule interacting drugs lead to peripheral neuropathy 471: Neuron defect induced early behavioral change
2506	1582: Impaired axonial transport	1944: Dysfunctional synapses	Oct 26, 2021	Oct 26, 2021	1 AOP 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
2012	1705: Impaired coordination and movement	351: Increased Mortality	Dec 20, 2019	Dec 20, 2019	1 AOP 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement
2015	1705: Impaired coordination and movement	360: Decrease, Population growth rate	Dec 20, 2019	Dec 20, 2019	1 AOP 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement
3260	364: Impaired development of, Reproductive organs	78: Reduction, Cumulative fecundity and spawning	Jul 3, 2024	Jul 3, 2024	1 AOP 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver

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