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Showing 1551 to 1575 of 3129 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1343	103: Increase, EcR hyperactivation	1264: Increase, E75b expression	Feb 9, 2017	Feb 9, 2017	1 AOP 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
3640	103: Increase, EcR hyperactivation	2373: Increase, Mis-timed EcR-responsive NR cascade	Sep 29, 2025	Sep 29, 2025	1 AOP 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
2200	1815: Increase, ER stress	1817: Apoptotic cell death	Nov 2, 2020	Nov 2, 2020	1 AOP 362: Immune mediated hepatitis
2643	1815: Increase, ER stress	1365: Increase, Apoptosis	Apr 8, 2022	Apr 8, 2022	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3737	1815: Increase, ER stress	55: Cell injury/death	Feb 11, 2026	Feb 11, 2026	2 AOPs 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
2778	2068: Increase, Endothelial Dysfunction	2003: Vascular remodeling	Sep 28, 2022	Sep 28, 2022	None
2784	2068: Increase, Endothelial Dysfunction	2069: Occurrence, Abnormal Vascular Remodeling	Oct 17, 2022	Aug 26, 2024	1 AOP 470: Deposition of energy leads to abnormal vascular remodeling
3373	2068: Increase, Endothelial Dysfunction	901: Infiltration, Inflammatory cells	Oct 30, 2024	Oct 30, 2024	1 AOP 462: Activation of reactive oxygen species leading the atherosclerosis
567	573: Increase, Energetic demands and therefore metabolic stress	574: Increased, Appetite and hunger	Nov 29, 2016	Dec 3, 2016	1 AOP 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
2330	1860: Excitation of intracellular water	1632: Increase in RONS	Apr 11, 2021	Apr 11, 2021	None
1708	1501: Increase, ECM deposition	1458: Pulmonary fibrosis	Jan 16, 2018	Dec 6, 2021	None
2325	1501: Increase, ECM deposition	344: Increase, Liver fibrosis	Apr 10, 2021	Feb 1, 2025	2 AOPs 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis 494: AhR activation leading to liver fibrosis
3546	2333: Increase, Fat mass	2335: Increase, BMI	Jul 25, 2025	Jul 25, 2025	1 AOP 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index
1417	1312: Increase, Fatty acid β-oxidation	1313: Decrease, cytosolic fatty acid	Apr 13, 2017	Apr 13, 2017	None
3676	1312: Increase, Fatty acid β-oxidation	1446: Decrease, Coupling of OXPHOS	Oct 30, 2025	Oct 30, 2025	2 AOPs 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
132	115: Increase, FA influx	291: Accumulation, Triglyceride	Nov 29, 2016	Mar 29, 2024	2 AOPs 34: LXR activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis
3723	115: Increase, FA influx	459: Increase, Liver steatosis	Feb 10, 2026	Feb 10, 2026	None
3687	1994: Ferroptosis	902: Inflammation, Liver	Nov 4, 2025	Nov 4, 2025	1 AOP 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
1597	1444: Increase, Follicular atresia	1366: Decrease, Oogenesis	Jun 29, 2017	Jun 29, 2017	2 AOPs 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia
2211	1444: Increase, Follicular atresia	328: Decrease, Fecundity	Nov 25, 2020	Nov 25, 2020	None
3097	1765: Increase, Formation of DNA photoproducts	1461: Increase, DSB	Nov 16, 2023	Nov 16, 2023	None
1462	1361: Increase, GABA	1359: Activate, GABA-A receptor	Apr 14, 2017	Apr 14, 2017	1 AOP 215: Molecular events lead to epilepsy
1885	1621: Increase, Gene expression	328: Decrease, Fecundity	Apr 22, 2019	Apr 22, 2019	None
1234	1175: Increase, Genes involved in fatty acid oxidation	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	None
1240	1175: Increase, Genes involved in fatty acid oxidation	1173: Increase, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids	Nov 29, 2016	Dec 3, 2016	None

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