Prototypical Stressors

Showing 276 to 300 of 853 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

17	Diethyl sulfate	Diethyl sulfate, CAS-RN: 64-67-5, DTXSID1024045	None
462	Diethylaminobenzaldehyde		297: Inhibition of retinaldehyde dehydrogenase leads to population decline
698	Diethylhexyl phthalate		431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
176	Diethylstilbestrol	Diethylstilbestrol, CAS-RN: 56-53-1, DTXSID3020465	167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
371	Diflubenzuron	Diflubenzuron, CAS-RN: 35367-38-5, DTXSID1024049	None
188	Diflunisal	Diflunisal, CAS-RN: 22494-42-4, DTXSID5022932	None
804	Digoxin		556: Decreased Na/K ATPase activity leading to heart failure
388	Diltiazem	(+)-Diltiazem, CAS-RN: 42399-41-7, DTXSID9022940	2 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
547	Dimethoate	Dimethoate, CAS-RN: 60-51-5, DTXSID7020479	None
308	Dimethyl dithiocarbamate		242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
637	Dimethyl fumarate		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
18	Dimethyl nitrosamine	N-Nitrosodimethylamine, CAS-RN: 62-75-9, DTXSID7021029	38: Protein Alkylation leading to Liver Fibrosis
19	Dimethyl sulfate	Dimethyl sulfate, CAS-RN: 77-78-1, DTXSID5024055	None
604	Dinoseb	Dinoseb, CAS-RN: 88-85-7, DTXSID3020207	263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
214	DIOFENOLAN	Diofenolan, CAS-RN: 63837-33-2, DTXSID2041884	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
349	dioxin		None
20	Dioxin and dioxin-like compounds	2,3,7,8-Tetrachlorodibenzo-p-dioxin, CAS-RN: 1746-01-6, DTXSID2021315 Acetamide, CAS-RN: 60-35-5, DTXSID7020005	None
199	diphacinone	Diphacinone, CAS-RN: 82-66-6, DTXSID4032378	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
412	Discodermolide		None
704	Disopyramide	Disopyramide, CAS-RN: 3737-09-5, DTXSID1045536	None
310	Disulfiram	Tetraethylthiuram disulfide, CAS-RN: 97-77-8, DTXSID1021322	2 AOPs 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
461	Disulphiram		297: Inhibition of retinaldehyde dehydrogenase leads to population decline
367	Diuron	Diuron, CAS-RN: 330-54-1, DTXSID0020446	2 AOPs 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
532	Dodecylbenzene sulfonate		154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
801	Dofetilide		555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure