Prototypical Stressors

Showing 276 to 300 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

873	Dibenz(a,h)anthracene	Dibenz(a,h)anthracene, CAS-RN: 53-70-3, DTXSID9020409	2 AOPs 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
147	Dibenzo-p-dioxin	Dibenzo-p-dioxin, CAS-RN: 262-12-4, DTXSID8020410	131: Aryl hydrocarbon receptor activation leading to uroporphyria
235	Dibenzo[B,F][1,4]Oxazepine		196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
159	dibenzofuran	Dibenzofuran, CAS-RN: 132-64-9, DTXSID2021993	None
14	Dibutyl phthalate	1,2-Benzenedicarboxylic acid, dibutyl ester, CAS-RN: 84-74-2, DTXSID2021781	4 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 619: Androgen receptor antagonism leads to delayed preputial separation via reduced fibroblast growth factor in genital-tubercle tissues
134	Dichloroacetic Acid	Dichloroacetic acid, CAS-RN: 79-43-6, DTXSID2020428	None
15	Diclofenac sodium	Diclofenac sodium, CAS-RN: 15307-79-6, DTXSID3037208	2 AOPs 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality
567	Dicyclohexyl phthalate	Dicyclohexyl phthalate, CAS-RN: 84-61-7, DTXSID5025021	None
115	Dieldrin	Dieldrin, CAS-RN: 60-57-1, DTXSID9020453	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
667	Diesel engine exhaust	Diesel engine exhaust, CAS-RN: NOCAS, DTXSID1024043	2 AOPs 411: Oxidative stress Leading to Decreased Lung Function 451: Interaction with lung resident cell membrane components leads to lung cancer
767	Diethyl maleate	Diethyl maleate, CAS-RN: 141-05-9, DTXSID8020464	492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
16	Diethyl nitrosamine	N-Nitrosodiethylamine, CAS-RN: 55-18-5, DTXSID2021028	None
17	Diethyl sulfate	Diethyl sulfate, CAS-RN: 64-67-5, DTXSID1024045	None
462	Diethylaminobenzaldehyde		297: Inhibition of retinaldehyde dehydrogenase leads to population decline
698	Diethylhexyl phthalate		431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
176	Diethylstilbestrol	Diethylstilbestrol, CAS-RN: 56-53-1, DTXSID3020465	167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
371	Diflubenzuron	Diflubenzuron, CAS-RN: 35367-38-5, DTXSID1024049	None
188	Diflunisal	Diflunisal, CAS-RN: 22494-42-4, DTXSID5022932	None
804	Digoxin		556: Decreased Na/K ATPase activity leading to heart failure
388	Diltiazem	(+)-Diltiazem, CAS-RN: 42399-41-7, DTXSID9022940	2 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
547	Dimethoate	Dimethoate, CAS-RN: 60-51-5, DTXSID7020479	None
308	Dimethyl dithiocarbamate		242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
637	Dimethyl fumarate		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
18	Dimethyl nitrosamine	N-Nitrosodimethylamine, CAS-RN: 62-75-9, DTXSID7021029	38: Protein Alkylation leading to Liver Fibrosis
19	Dimethyl sulfate	Dimethyl sulfate, CAS-RN: 77-78-1, DTXSID5024055	None