AOP-Wiki

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All Key Events

Showing 801 to 825 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1247	EGFR , PPAR-alpha activation Short Name EGFR , PPAR-alpha activation	0		Nov 29, 2016	Nov 29, 2016	None
1248	EGFR , Activation Short Name EGFR , Activation	0		Nov 29, 2016	Nov 29, 2016	None
1250	Decrease, Lung function Short Name Decreased lung function	1	Individual	Nov 29, 2016	Sep 8, 2021	7 AOPs 148: EGFR Activation Leading to Decreased Lung Function 302: Lung surfactant function inhibition leading to decreased lung function 411: Oxidative stress Leading to Decreased Lung Function 418: Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway 419: Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
1251	Chronic, Mucus hypersecretion Short Name Chronic, Mucus hypersecretion	1	Tissue	Nov 29, 2016	Aug 25, 2021	None
1252	Binding to (interferes with) topoisomerase II enzyme Short Name Binding, topoisomerase II	1	Molecular	Dec 16, 2016	Aug 1, 2022	202: Inhibitor binding to topoisomerase II leading to infant leukaemia
1253	MLL chromosomal translocation Short Name MLL translocation	1	Cellular	Dec 16, 2016	Aug 1, 2022	202: Inhibitor binding to topoisomerase II leading to infant leukaemia
1254	Infant leukaemia Short Name IFL	0	Individual	Dec 16, 2016	Aug 1, 2022	202: Inhibitor binding to topoisomerase II leading to infant leukaemia
1255	induced spawning Short Name induced spawning	1	Individual	Jan 13, 2017	Jan 13, 2017	195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
1256	increased mantel display Short Name increased mantel display	0	Organ	Jan 13, 2017	Jan 13, 2017	2 AOPs 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
1257	Induced parturition Short Name Induced parturition	0	Individual	Jan 13, 2017	Jan 13, 2017	2 AOPs 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
1258	Decompartmentalization Short Name Decompartmentalization	1	Cellular	Feb 7, 2017	Sep 16, 2017	205: AOP from chemical insult to cell death
1259	narcosis Short Name narcosis	1	Cellular	Feb 7, 2017	Sep 16, 2017	205: AOP from chemical insult to cell death
1260	Direct mitochondrial inhibition Short Name Direct mitochondrial inhibition	1	Molecular	Feb 7, 2017	Sep 16, 2017	205: AOP from chemical insult to cell death
1262	Apoptosis Short Name Apoptosis	1	Cellular	Feb 7, 2017	May 31, 2025	19 AOPs 205: AOP from chemical insult to cell death 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans 212: Histone deacetylase inhibition leading to testicular atrophy 285: Inhibition of N-linked glycosylation leads to liver injury 419: Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway 439: Activation of the AhR leading to metastatic breast cancer 452: Adverse outcome pathway of PM-induced respiratory toxicity 393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 502: Decrease, cholesterol synthesis leads to orofacial clefting 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation 535: Binding and activation of GPER leading to learning and memory impairments 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis 595: Emerging OPFRS reproductive outcome pathway 616: organic UV filter and its Photoproducts reproductive toxicity pathways
1263	Necrosis Short Name Necrosis	1	Tissue	Feb 7, 2017	Feb 7, 2017	205: AOP from chemical insult to cell death
1264	Increase, Nuclear receptor E75b gene expression Short Name Increase, E75b expression	1	Molecular	Feb 9, 2017	May 24, 2018	4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
1265	Decrease, Fushi tarazu factor-1 gene expression Short Name Decrease, Ftz-f1 expression	1	Molecular	Feb 9, 2017	Sep 26, 2025	4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
1266	Decrease, Circulating crustacean cardioactive peptide Short Name Decrease, Circulating CCAP	1	Tissue	Feb 9, 2017	May 24, 2018	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
1267	Decrease, Ecdysis motor program activity Short Name	1	Tissue	Feb 9, 2017	Sep 29, 2025	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
1268	Decrease, Excitatory postsynaptic potential Short Name	1	Tissue	Feb 9, 2017	May 24, 2018	None
1269	Increase, COX-2 expression Short Name Increase, COX-2 expression	1	Molecular	Feb 9, 2017	Mar 20, 2018	21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
1270	Inactivation of PPARγ Short Name Inactivation of PPARγ	0	Molecular	Feb 15, 2017	Dec 26, 2017	2 AOPs 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
1271	Increase, Transforming growth factor-beta signaling Short Name Activation of TGF-β signaling	0	Molecular	Feb 15, 2017	Feb 11, 2026	7 AOPs 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
1272	Increase, Myofibroblast expansion Short Name Increase, Myofibroblast expansion	0	Cellular	Feb 15, 2017	Feb 10, 2026	None
1273	Expression of Collagen Short Name Expression of Collagen	0	Cellular	Feb 15, 2017	Feb 15, 2017	None