AOP-Wiki

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All Key Events

Showing 726 to 750 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1678	Impaired oxygenation of the blood Short Name Impaired oxygenation of the blood	0	Organ	Jul 3, 2019	Jul 3, 2019	None
1677	Reduced tidal volume Short Name Reduced tidal volume	0	Organ	Jul 3, 2019	Feb 16, 2021	302: Lung surfactant function inhibition leading to decreased lung function
1676	Blood extravasation into the lungs Short Name Blood extravasation into the lungs	0	Organ	Jul 3, 2019	Jul 3, 2019	None
1675	Loss of barrier function Short Name Loss of barrier function	0	Tissue	Jul 3, 2019	Jul 3, 2019	None
1674	Alveolar reopening Short Name Alveolar reopening	0	Tissue	Jul 3, 2019	Jul 3, 2019	None
1673	Alveolar collapse Short Name Alveolar collapse	0	Cellular	Jul 3, 2019	Oct 27, 2021	302: Lung surfactant function inhibition leading to decreased lung function
1672	Inhibition of lung surfactant function Short Name Inhibition of LS function.	0	Molecular	Jul 3, 2019	Oct 27, 2021	302: Lung surfactant function inhibition leading to decreased lung function
1671	Substance - lung surfactant interaction Short Name Substance - LS interaction	0	Molecular	Jul 3, 2019	Jul 3, 2019	None
1670	Lung cancer Short Name Lung cancer	2	Organ	Jul 3, 2019	Aug 13, 2019	5 AOPs 303: Frustrated phagocytosis-induced lung cancer 416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway 417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway 420: Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway 451: Interaction with lung resident cell membrane components leads to lung cancer
1669	Increased, DNA damage and mutation Short Name Increased, DNA damage and mutation	5	Cellular	Jul 3, 2019	Aug 13, 2019	6 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma 416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway 417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway 443: DNA damage and mutations leading to Metastatic Breast Cancer 451: Interaction with lung resident cell membrane components leads to lung cancer
1668	Frustrated phagocytosis Short Name Frustrated phagocytosis	1	Cellular	Jul 3, 2019	Sep 16, 2022	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma
1667	Impaired,anterior-posterior axis development Short Name anterior-posterior axis development	0	Individual	Jul 3, 2019	Jul 3, 2019	301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
1666	Induced, dysfunction of microcirculation Short Name dysfunction of microcirculation	0	Organ	Jul 3, 2019	Jul 3, 2019	2 AOPs 301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis 426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1665	Increased, Plasma HCY level Short Name Plasma HCY level	0	Tissue	Jul 3, 2019	Jul 3, 2019	301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
1664	Induce Neuronal dysfunctions Short Name Neuronal dysfunctions induction	0	Individual	Jun 14, 2019	Jun 14, 2019	None
1663	Increased brain Homocysteine level Short Name brain Homocysteine level increases	0	Organ	Jun 14, 2019	Jun 14, 2019	None
1662	Increased plasma Homocysteine level Short Name plasma homocysteine increases	0	Tissue	Jun 14, 2019	Jun 14, 2019	None
1661	Increased Homocysteine level Short Name Homocysteine increases	0	Cellular	Jun 14, 2019	Jun 14, 2019	301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
1660	Inhibition of betaine-homocysteine methyltransferase Short Name	0	Molecular	Jun 14, 2019	Jun 14, 2019	None
1659	Inhibition of Methylenetetrahydrofolate reductase Short Name MTHFR inhibition	0	Molecular	Jun 14, 2019	Jun 14, 2019	None
1658	Inhibition of Methionine synthase Short Name Methionine synthase	0	Molecular	Jun 14, 2019	Jun 14, 2019	None
1657	Inhibition of cystathionine beta-synthase Short Name CBS inhibition	0	Molecular	Jun 14, 2019	Jun 14, 2019	301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
1656	Antagonism, Thyroid Receptor Short Name TR Antagnoism	0	Molecular	Jun 8, 2019	Apr 27, 2026	4 AOPs 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1655	Binding of inhibitor to mitochondrial complex V Short Name	0	Molecular	Jun 7, 2019	Jun 7, 2019	273: Mitochondrial complex inhibition leading to liver injury
1654	Binding of inhibitor to mitochondrial complex IV Short Name	0	Molecular	Jun 7, 2019	Jun 7, 2019	273: Mitochondrial complex inhibition leading to liver injury