AOP-Wiki

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All Key Events

Showing 1026 to 1050 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1365	Increase, Apoptosis Short Name Increase, Apoptosis	0	Cellular	Apr 15, 2017	Apr 15, 2017	5 AOPs 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 330: Excessive reactive oxygen species production leading to mortality (4) 622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure
1363	Increased, epilepsy Short Name Increased, epilepsy	0	Individual	Apr 14, 2017	Jun 2, 2017	4 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy 471: Neuron defect induced early behavioral change
1362	Increased, hippocampal hyperdepolarization Short Name	0	Molecular	Apr 14, 2017	Jun 2, 2017	3 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy
1361	Increase, GABA Short Name Increase, GABA	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1360	Activate, presynaptic neuron 2 Short Name Activate, presynaptic neuron 2	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1359	Activate, GABA-A receptor Short Name Activate, GABA-A receptor	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1358	Repress, GABA-A receptor Short Name Repress, GABA-A receptor	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1357	Increased, RDX dose Short Name Increased, RDX dose	0	Molecular	Apr 14, 2017	Jun 2, 2017	2 AOPs 215: Molecular events lead to epilepsy 231: presynaptic neuron 2 repression to epilepsy
1356	Inactive, membrane depolarization Short Name Inactive, membrane depolarization	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1355	Activated, membrane depolarization Short Name Activated, membrane depolarization	0	Cellular	Apr 14, 2017	Jun 2, 2017	3 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy
1354	Treat, carbamazepine Short Name Treat, carbamazepine	0	Molecular	Apr 14, 2017	Apr 14, 2017	2 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy
1353	Binding to voltage-gated sodium channel Short Name Binding to VGSC	1	Molecular	Apr 14, 2017	Jul 31, 2024	4 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 442: Binding to voltage gate sodium channels during development leads to cognitive impairment 489: Inhibition of voltage-gated sodium channels leading to decreased cognition
1352	Activated, voltage-gated sodium channel Short Name Activated, voltage-gated sodium channel	0	Molecular	Apr 14, 2017	Jun 2, 2017	2 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy
1351	Activated, NMDA receptor Short Name Activated, NMDA receptor	0	Molecular	Apr 14, 2017	Jun 2, 2017	2 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy
1350	Increased, glutamate Short Name Increased, glutamate	1	Molecular	Apr 14, 2017	Oct 11, 2021	4 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
1349	Activated, presynaptic neuron 1 Short Name Activated, presynaptic neuron 1	0	Molecular	Apr 14, 2017	Jun 2, 2017	3 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 471: Neuron defect induced early behavioral change
1348	Increase, seizure Short Name Increase, seizure	0	Individual	Apr 14, 2017	Apr 14, 2017	3 AOPs 215: Molecular events lead to epilepsy 402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain 471: Neuron defect induced early behavioral change
1347	Decreased, extracellular serotonin Short Name Decreased, extracellular serotonin	0	Molecular	Apr 14, 2017	May 31, 2017	7 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1346	Increased, depression Short Name Increased, depression	0	Individual	Apr 13, 2017	Feb 6, 2026	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 224: Serotonin transporter activation to depression 604: Binding of Alpha 1-Adrenergics to Agonists Leading to Depression
1345	Increased, agitation Short Name Increased, agitation	0	Molecular	Apr 13, 2017	Jun 1, 2017	3 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 222: Mental stress to agitation 225: Serotonin transporter activation to agitation
1344	Increased, seizure Short Name Increased, seizure	0	Individual	Apr 13, 2017	Jun 1, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 223: Serotonin transporter activation to seizure 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy
1343	Increase, hypertension Short Name Increase, hypertension	0	Individual	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1342	Increase, vascular smooth muscle contraction Short Name	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1341	Increase, myosin light chain phosphorylation Short Name	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1340	Activate, calmodulin Short Name Activate, calmodulin	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension