Key Event Relationships (KERs)

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Showing 2501 to 2525 of 3081 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1901 1494: Leukocyte recruitment/activation 1182: Increase, Cell Proliferation (Epithelial Cells) May 7, 2019 May 7, 2019 None
1905 1494: Leukocyte recruitment/activation 1632: Increase in RONS May 7, 2019 May 9, 2019
2891 1494: Leukocyte recruitment/activation 1501: Increase, ECM deposition Apr 13, 2023 Apr 13, 2023 None
1728 1511: Lipid Peroxidation 1509: Protein Adduct Formation Apr 4, 2018 Apr 5, 2018
1731 1511: Lipid Peroxidation 1513: General Apoptosis Apr 4, 2018 Apr 5, 2018
3377 1511: Lipid Peroxidation 1442: Foam cell formation Oct 30, 2024 Oct 30, 2024 None
3686 2386: Lipid-peroxidation overload 1994: Ferroptosis Nov 4, 2025 Nov 4, 2025 None
1500 1389: Locomotor activity, decreased 1141: Decreased, Reproductive Success May 8, 2017 Jun 26, 2017
1705 1498: Loss of alveolar capillary membrane integrity 1499: Activation of Th2 cells Jan 5, 2018 May 16, 2023
2174 1498: Loss of alveolar capillary membrane integrity 1676: Blood extravasation into the lungs Oct 22, 2020 Oct 22, 2020 None
2258 1498: Loss of alveolar capillary membrane integrity 1833: Impaired lung function Jan 8, 2021 Jan 8, 2021 None
2259 1498: Loss of alveolar capillary membrane integrity 1671: Substance - LS interaction Jan 8, 2021 Jan 8, 2021 None
2368 1498: Loss of alveolar capillary membrane integrity 1672: Inhibition of LS function. Apr 27, 2021 Apr 27, 2021
2369 1498: Loss of alveolar capillary membrane integrity 1677: Reduced tidal volume Apr 27, 2021 Apr 27, 2021
2372 1498: Loss of alveolar capillary membrane integrity 1250: Decreased lung function Apr 27, 2021 Apr 27, 2021
1972 1675: Loss of barrier function 1676: Blood extravasation into the lungs Jul 3, 2019 Jul 3, 2019 None
2807 2078: Loss of drebrin 1944: Dysfunctional synapses Dec 11, 2022 Apr 4, 2025
3298 2078: Loss of drebrin 2242: Dendritic spine abnormality Jul 14, 2024 Apr 4, 2025
3300 2078: Loss of drebrin 341: Impairment, Learning and memory Jul 14, 2024 Mar 9, 2025
405 348: Malformation, Male reproductive tract 406: decreased, Fertility Nov 29, 2016 Dec 2, 2016
808 809: malformed, Male reproductive tract 330: Decrease, Fertility Nov 29, 2016 Dec 3, 2016
402 409: Metabolism of AFB1, Production of Reactive Electrophiles 373: Formation, Pro-mutagenic DNA Adducts Nov 29, 2016 Nov 29, 2016
3688 2387: Nuclear receptor binding / steroidogenic enzyme interference 2389: Altered steroidogenesis Nov 7, 2025 Nov 7, 2025
3689 2388: photoproducts generate ROS 1392: Increase, Oxidative Stress Nov 7, 2025 Nov 7, 2025
3695 2388: photoproducts generate ROS 2389: Altered steroidogenesis Nov 7, 2025 Nov 7, 2025