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All KERs

Showing 76 to 100 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

451	12: AchE Inhibition	39: Increased Cholinergic Signaling	Nov 29, 2016	Dec 20, 2019	2 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement
452	12: AchE Inhibition	351: Increased Mortality	Nov 29, 2016	Dec 20, 2019	1 AOP 16: Acetylcholinesterase inhibition leading to acute mortality
453	12: AchE Inhibition	442: Decreased, Population trajectory	Nov 29, 2016	Dec 20, 2019	None
2007	12: AchE Inhibition	1703: Cardiovascular dysregulation	Nov 25, 2019	Dec 20, 2019	1 AOP 16: Acetylcholinesterase inhibition leading to acute mortality
2014	12: AchE Inhibition	1705: Impaired coordination and movement	Dec 20, 2019	Dec 20, 2019	1 AOP 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement
2016	12: AchE Inhibition	360: Decrease, Population growth rate	Dec 20, 2019	Dec 20, 2019	1 AOP 16: Acetylcholinesterase inhibition leading to acute mortality
2653	12: AchE Inhibition	1391: Activation of Cyp2E1	May 16, 2022	May 16, 2022	1 AOP 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
3063	12: AchE Inhibition	2195: Increase, CNS Neural cell death	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
3064	12: AchE Inhibition	1944: Dysfunctional synapses	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
3430	12: AchE Inhibition	1602: Activation, Muscarinic Acetylcholine Receptors	Nov 22, 2024	Nov 22, 2024	1 AOP 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
2032	1724: Acinar cell proliferation	1725: Acinar cell tumors	Jan 8, 2020	Jan 8, 2020	1 AOP 316: Trypsin inhibition leading to pancreatic acinar cell tumors
1442	1340: Activate, calmodulin	1341: Increase, myosin light chain phosphorylation	Apr 14, 2017	Apr 14, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1464	1359: Activate, GABA-A receptor	1322: Increased, intracellular chloride (Cl-)	Apr 14, 2017	Apr 14, 2017	1 AOP 215: Molecular events lead to epilepsy
1476	1379: Activate, leukocyte	1385: Activated, gastric ulcer formation	Apr 17, 2017	Apr 17, 2017	1 AOP 217: Gastric ulcer formation
1475	1380: Activate, mucosal defense	1367: Inhibit, gastric ulcer formation	Apr 17, 2017	Apr 17, 2017	1 AOP 217: Gastric ulcer formation
1488	1383: Activate, phospholipase	1382: Decrease, surfactant	Apr 17, 2017	Apr 17, 2017	2 AOPs 217: Gastric ulcer formation 229: Helicobacter pylori to gastric ulcer
1439	1337: Activate, PLC	1338: Increase, inositol triphosphate	Apr 14, 2017	Apr 14, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1461	1360: Activate, presynaptic neuron 2	1361: Increase, GABA	Apr 14, 2017	Apr 14, 2017	1 AOP 215: Molecular events lead to epilepsy
3015	2173: Activated AKT/ERK/PI3K pathway	2161: Increase, Vascular disrupting effects	Aug 21, 2023	Aug 21, 2023	None
3024	2173: Activated AKT/ERK/PI3K pathway	1928: increased，Vascular endothelial dysfunction	Aug 21, 2023	Aug 21, 2023	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3010	2170: Activated ANG/Tie2 pathway	2161: Increase, Vascular disrupting effects	Aug 21, 2023	Aug 21, 2023	None
3020	2170: Activated ANG/Tie2 pathway	1928: increased，Vascular endothelial dysfunction	Aug 21, 2023	Aug 21, 2023	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3012	2171: Activated BMP/TGF-beta pathway	2161: Increase, Vascular disrupting effects	Aug 21, 2023	Aug 21, 2023	None
3021	2171: Activated BMP/TGF-beta pathway	1928: increased，Vascular endothelial dysfunction	Aug 21, 2023	Aug 21, 2023	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3013	2172: Activated Wnt/Frizzled pathway	2161: Increase, Vascular disrupting effects	Aug 21, 2023	Aug 21, 2023	None

Key Event Relationships (KERs)

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