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All KERs

Showing 976 to 1000 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

772	749: Decreased, Progesterone from corpus luteum	772: Increase, Hyperplasia (glandular epithelial cells of endometrium)	Nov 29, 2016	Dec 3, 2016	1 AOP 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
1988	1693: Decreased, Progesterone levels	1694: Reduction, progesterone uptake, decresed maturation	Oct 3, 2019	Oct 3, 2019	1 AOP 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
3521	1693: Decreased, Progesterone levels	1611: Reduction, androstenedione	Apr 8, 2025	Apr 8, 2025	None
3524	747: Decreased, Prolactin	111: Agonism, Estrogen receptor	Apr 17, 2025	Apr 17, 2025	1 AOP 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
1138	1104: Decreased, Prostaglandin F2alpha concentration, plasma	1105: Occurrence, renal ischemia	Nov 29, 2016	Dec 3, 2016	1 AOP 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
682	681: Decreased, Prostaglandin F2alpha synthesis, ovary	671: Reduced, Prostaglandin F2alpha concentration, plasma	Nov 29, 2016	Dec 3, 2016	1 AOP 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
3647	968: Decreased, release of kisspeptin from AVPV neurons	530: Decreased, GnRH pulsatility/release	Oct 2, 2025	Jun 2, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
832	825: Decreased, Renal ability to dilute urine	814: Occurrence, Kidney toxicity	Nov 29, 2016	Dec 3, 2016	1 AOP 128: Kidney dysfunction by decreased thyroid hormone
830	820: Decreased, Renal plasma flow	814: Occurrence, Kidney toxicity	Nov 29, 2016	Dec 3, 2016	1 AOP 128: Kidney dysfunction by decreased thyroid hormone
2635	1141: Decreased, Reproductive Success	360: Decrease, Population growth rate	Apr 6, 2022	Apr 6, 2022	3 AOPs 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
3777	2419: Decreased, RAR activation	1882: Disrupted, meiotic initiation in oocyte	Apr 24, 2026	Apr 24, 2026	1 AOP 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia
1426	1317: Decreased, serotonin transporter activity	1321: Increased, intracellular sodium (Na+)	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
1427	1317: Decreased, serotonin transporter activity	1322: Increased, intracellular chloride (Cl-)	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
1428	1317: Decreased, serotonin transporter activity	1318: Decreased, extracellular Na+	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
1429	1317: Decreased, serotonin transporter activity	1319: Decreased, extracellular chloride (Cl-)	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
1430	1317: Decreased, serotonin transporter activity	1320: Increased, extracellular serotonin	Apr 14, 2017	Apr 14, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1431	1317: Decreased, serotonin transporter activity	1323: Decreased, intracellular serotonin	Apr 14, 2017	Apr 14, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1065	1022: Decreased, serum T4/T3	1023: Increased, Thyroid-stimulating hormone (TSH)	Nov 29, 2016	Dec 3, 2016	None
646	629: Decreased, sheltering	588: Increased, predation	Nov 29, 2016	Dec 3, 2016	1 AOP 98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
2480	1883: Decreased, ovarian reserve	972: Decreased fertility, Reduced number of oocytes ovulated	Sep 12, 2021	Sep 12, 2021	None
2487	1883: Decreased, ovarian reserve	406: decreased, Fertility	Oct 10, 2021	Oct 10, 2021	None
2525	1883: Decreased, ovarian reserve	405: disrupted, ovarian cycle	Oct 29, 2021	Dec 18, 2024	1 AOP 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia
3483	1883: Decreased, ovarian reserve	2305: POI	Jan 22, 2025	May 31, 2025	1 AOP 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
586	585: Decreased, Sodium conductance 1	586: Reduced, swimming speed	Nov 29, 2016	Dec 3, 2016	3 AOPs 91: Sodium channel inhibition leading to reduced survival 93: sodium channel inhibition leading to increased predation 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
594	585: Decreased, Sodium conductance 1	444: Increased, Atrioventricular block and bradycardia	Nov 29, 2016	Dec 3, 2016	1 AOP 94: Sodium channel inhibition leading to congenital malformations

Key Event Relationships (KERs)

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