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All KERs

Showing 976 to 1000 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

586	585: Decreased, Sodium conductance 1	586: Reduced, swimming speed	Nov 29, 2016	Dec 3, 2016	3 AOPs 91: Sodium channel inhibition leading to reduced survival 93: sodium channel inhibition leading to increased predation 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
594	585: Decreased, Sodium conductance 1	444: Increased, Atrioventricular block and bradycardia	Nov 29, 2016	Dec 3, 2016	1 AOP 94: Sodium channel inhibition leading to congenital malformations
1243	1176: Decreased, sodium conductance 2	1177: Decreased, Ionotropic GABA receptor chloride channel conductance	Nov 29, 2016	Dec 3, 2016	None
1244	1176: Decreased, sodium conductance 2	1179: Decreased, GABA release	Nov 29, 2016	Dec 3, 2016	1 AOP 197: Sodium channel (Nav1.1) inhibition leading to population decline
831	821: Decreased, Sodium reabsorption	814: Occurrence, Kidney toxicity	Nov 29, 2016	Dec 3, 2016	1 AOP 128: Kidney dysfunction by decreased thyroid hormone
3288	2236: Decreased, sodium uptake in gills	2237: Decreased, Plasma sodium concentrations	Jul 8, 2024	Dec 3, 2024	1 AOP 539: Decreased Sodium/Potassium ATPase activity leads to Heart failure
3168	647: Decreased, steroidogenic protein expression	1690: Decrease, circulating testosterone levels	Mar 20, 2024	Dec 3, 2024	1 AOP 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis
3171	647: Decreased, steroidogenic protein expression	1613: Decrease, DHT level	Mar 20, 2024	Dec 3, 2024	1 AOP 527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
1434	1325: Decreased, synaptic release	1347: Decreased, extracellular serotonin	Apr 14, 2017	Apr 14, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 222: Mental stress to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension 221: Mental stress to depression
1001	989: Decreased, synthesis and secretion of molting fluid proteases	990: Increase, Incomplete ecdysis	Nov 29, 2016	Dec 3, 2016	None
1009	994: Decreased, Synthesis of molting fluid proteases	996: Decrease, Digestion of old cuticle	Nov 29, 2016	Dec 3, 2016	None
730	743: Decreased, Testosterone binding to androgen receptor (hypothalamus)	744: Increase, Hyperplasia (Leydig cells)	Nov 29, 2016	Dec 3, 2016	None
744	743: Decreased, Testosterone binding to androgen receptor (hypothalamus)	754: Increased, Luteinizing hormone (LH)	Nov 29, 2016	Dec 3, 2016	1 AOP 111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
1142	1093: Decreased, Thyroxine (T4) in tissues	1101: Altered, Amphibian metamorphosis	Nov 29, 2016	Dec 3, 2016	None
1163	1093: Decreased, Thyroxine (T4) in tissues	1116: Decreased, Triiodothyronine (T3) in tissues	Nov 29, 2016	Dec 3, 2016	None
1027	1003: Decreased, Triiodothyronine (T3)	1004: Reduced, Posterior swim bladder inflation	Nov 29, 2016	Oct 7, 2022	2 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
1035	1003: Decreased, Triiodothyronine (T3)	1007: Reduced, Anterior swim bladder inflation	Nov 29, 2016	Oct 7, 2022	3 AOPs 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
2373	1003: Decreased, Triiodothyronine (T3)	1877: Altered, retinal layer structure	May 11, 2021	Jul 8, 2022	1 AOP 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
2376	1003: Decreased, Triiodothyronine (T3)	1878: Decreased, Eye size	May 11, 2021	Jun 16, 2021	1 AOP 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size
2378	1003: Decreased, Triiodothyronine (T3)	1640: Altered, Photoreceptor patterning	May 11, 2021	Oct 17, 2021	1 AOP 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
1164	1116: Decreased, Triiodothyronine (T3) in tissues	1101: Altered, Amphibian metamorphosis	Nov 29, 2016	Dec 3, 2016	1 AOP 189: Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis
2238	1116: Decreased, Triiodothyronine (T3) in tissues	1023: Increased, Thyroid-stimulating hormone (TSH)	Dec 9, 2020	Dec 9, 2020	1 AOP 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
2239	1116: Decreased, Triiodothyronine (T3) in tissues	1829: Altered, TH-dependent gene expression	Dec 9, 2020	Dec 9, 2020	1 AOP 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
768	737: Decreased, Uptake of inorganic iodide	771: Decrease, Serum thyroid hormone (T4/T3)	Nov 29, 2016	Dec 3, 2016	None
2421	737: Decreased, Uptake of inorganic iodide	277: TH synthesis, Decreased	Jul 7, 2021	Jul 7, 2021	None

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