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All KERs

Showing 1476 to 1500 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1676	709: Increase, Cytotoxicity (renal tubular cell)	814: Occurrence, Kidney toxicity	Oct 25, 2017	Mar 8, 2022	4 AOPs 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity 258: Renal protein alkylation leading to kidney toxicity 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
784	783: Increase, Cytotoxicity (tubular epithelial cells)	710: Increase, Regenerative cell proliferation (tubular epithelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
796	794: Increase, Cytotoxicity (urothelial cells)	795: Increase, Regenerative cell proliferation (urothelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
1736	1516: Increase, D1 protein antagonism	1517: Decrease, PSII activity	May 24, 2018	May 24, 2018	None
2332	1861: D1 protein deactivation	1862: Decrease, Photosystem II efficiency	Apr 11, 2021	Apr 11, 2021	None
1405	1306: Increase, De novo lipogenesis	1305: Increase, cytosolic fatty acid	Apr 12, 2017	Apr 12, 2017	None
3735	1306: Increase, De novo lipogenesis	459: Increase, Liver steatosis	Feb 11, 2026	Feb 11, 2026	3 AOPs 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
2746	2053: Increase, Defects in tanning of new cuticle	2054: Increase, impairment of cuticle sclerotization	Aug 28, 2022	Aug 28, 2022	1 AOP 466: Doda decarboxylase leading to mortality
2747	2053: Increase, Defects in tanning of new cuticle	2055: Increase, pigmentation	Aug 28, 2022	Aug 28, 2022	1 AOP 466: Doda decarboxylase leading to mortality
2743	2050: Increase, developmental abnormalities	350: Increase, Mortality	Aug 28, 2022	Aug 28, 2022	2 AOPs 465: Alcohol dehydrogenase leading to reproductive dysfunction 467: Knickkopf leading to mortality
3547	2334: Increase, DGAT1	2332: Increase, Lipid droplet	Jul 25, 2025	Jul 25, 2025	1 AOP 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index
1626	1456: Differentiation of fibroblasts	1273: Expression of Collagen	Jul 26, 2017	Jul 26, 2017	None
1654	1456: Differentiation of fibroblasts	68: Increase, Collagen accumulation	Aug 16, 2017	Aug 16, 2017	1 AOP 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
1301	1194: Increase, DNA Damage	1239: Altered, Gene Expression	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1468	1194: Increase, DNA Damage	1365: Increase, Apoptosis	Apr 15, 2017	Apr 15, 2017	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
1897	1194: Increase, DNA Damage	185: Increase, Mutations	May 7, 2019	May 8, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
1898	1194: Increase, DNA Damage	1492: Tissue resident cell activation	May 7, 2019	May 10, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
1899	1194: Increase, DNA Damage	1553: Increase mutations	May 7, 2019	May 7, 2019	None
2338	1194: Increase, DNA Damage	1864: Increase, Programmed cell death	Apr 11, 2021	Apr 11, 2021	1 AOP 388: Deposition of ionising energy leading to population decline via programmed cell death
2381	1194: Increase, DNA Damage	752: Altered, Meiotic chromosome dynamics	May 12, 2021	May 12, 2021	2 AOPs 396: Deposition of ionizing energy leads to population decline via impaired meiosis 435: Deposition of ionising energy leads to population decline via pollen abnormal
2382	1194: Increase, DNA Damage	1775: Increase, Oocyte apoptosis	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2595	1194: Increase, DNA Damage	1974: Activation of TP53	Mar 9, 2022	Mar 9, 2022	1 AOP 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
2622	1194: Increase, DNA Damage	1798: Decreased spermatogenesis	Mar 28, 2022	Mar 28, 2022	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2790	1194: Increase, DNA Damage	1505: Cell cycle, disrupted	Oct 25, 2022	Oct 25, 2022	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
3582	1194: Increase, DNA Damage	2344: Upregulation, gadd45ba	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration

Key Event Relationships (KERs)

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