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Showing 2301 to 2325 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2428	295: Induction, Upregulation of glucuronyltransferase activity	1021: Increased, T4/T3 catabolism	Jul 7, 2021	Jul 7, 2021	None
2478	295: Induction, Upregulation of glucuronyltransferase activity	961: Increased, Clearance of thyroxine from serum	Sep 10, 2021	Sep 10, 2021	4 AOPs 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
2483	295: Induction, Upregulation of glucuronyltransferase activity	281: T4 in serum, Decreased	Sep 14, 2021	Sep 14, 2021	None
2884	295: Induction, Upregulation of glucuronyltransferase activity	2133: Increase, Glucuronidation of T4	Apr 12, 2023	Apr 12, 2023	None
916	901: Infiltration, Inflammatory cells	902: Inflammation, Liver	Nov 29, 2016	Nov 29, 2016	None
3374	901: Infiltration, Inflammatory cells	1198: Activation, Macrophages	Oct 30, 2024	Oct 30, 2024	1 AOP 462: Activation of reactive oxygen species leading the atherosclerosis
926	907: Infiltration, Inflammatory cytokines	902: Inflammation, Liver	Nov 29, 2016	Dec 3, 2016	None
1855	1599: Inflammatory events	1600: Eczematous eruption	Feb 4, 2019	Feb 4, 2019	None
2916	1599: Inflammatory events	1196: Increased, Invasion	May 11, 2023	May 11, 2023	1 AOP 495: Androgen receptor activation leading to prostate cancer
2917	1599: Inflammatory events	2136: prostatic intraepithelial neoplasia	May 11, 2023	May 11, 2023	1 AOP 495: Androgen receptor activation leading to prostate cancer
2978	2158: IAV binds receptor	2159: IAV cell entry	Aug 11, 2023	Jan 18, 2024	1 AOP 506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
3055	2193: IAV budding	2194: infection proliferation	Oct 3, 2023	Oct 3, 2023	1 AOP 506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
3030	2159: IAV cell entry	2180: immune mechanisms antagonized	Aug 23, 2023	Aug 23, 2023	1 AOP 506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
3053	2192: IAV production increased	2193: IAV budding	Oct 3, 2023	Oct 3, 2023	1 AOP 506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
1520	1316: Inhibit, serotonin transporter activity	1317: Decreased, serotonin transporter activity	May 30, 2017	May 30, 2017	None
2707	2039: Inhibition, GABAAr	1527: Increase, Cell membrane depolarization	Jul 25, 2022	Jul 25, 2022	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
3595	2349: Inhibition of LDH activity	2350: Decreased, Glycolysis	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
2162	1799: Inhibition of 11β-HSD	1756: Decreased, 11KT	Jul 13, 2020	Jul 13, 2020	1 AOP 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
1952	1660: betaine-homocysteine methyltransferase inhibition	1661: Homocysteine increases	Jun 14, 2019	Jun 14, 2019	None
2694	2023: Inhibition CerS	2024: Reduced complex sphingolipids	Jul 19, 2022	Jul 20, 2022	1 AOP 449: Ceramide synthase inhibition leading to neural tube defects
2697	2023: Inhibition CerS	2033: Increased S1-P	Jul 19, 2022	Jul 19, 2022	1 AOP 449: Ceramide synthase inhibition leading to neural tube defects
1949	1657: CBS inhibition	1661: Homocysteine increases	Jun 14, 2019	Jun 14, 2019	1 AOP 301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
3433	2290: if	2291: Bradycardia	Nov 22, 2024	Nov 22, 2024	1 AOP 560: Inhibition of Funny current (If) leading to Arrhythmias
2402	1884: Inhibition of Fyna	1885: Inhibition of Plxna2	May 28, 2021	Dec 12, 2021	1 AOP 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
2539	1960: Inhibition of Ikr	1961: Prolongation of Action Potential	Dec 13, 2021	Dec 13, 2021	None

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