Key Event Relationships (KERs)

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Showing 1676 to 1700 of 3081 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
3164 177: Increase, Mitochondrial dysfunction 1917: Altered expression of NRF2 pathway-dependent genes Mar 14, 2024 Mar 14, 2024
3165 177: Increase, Mitochondrial dysfunction 202: Inhibition, Nuclear factor kappa B (NF-kB) Mar 14, 2024 Mar 14, 2024
2797 2072: Increase, Mitochondrial swelling 55: Cell injury/death Nov 1, 2022 Nov 1, 2022
198 350: Increase, Mortality 328: Decrease, Fecundity Nov 29, 2016 Dec 3, 2016 None
199 350: Increase, Mortality 361: Decline, Population Nov 29, 2016 Dec 3, 2016 None
1004 350: Increase, Mortality 765: Decreased, population 1 Nov 29, 2016 Dec 3, 2016 None
1013 350: Increase, Mortality 997: Decreased, Population size Nov 29, 2016 Dec 3, 2016 None
2463 350: Increase, Mortality 360: Decrease, Population growth rate Aug 5, 2021 Aug 5, 2021 None
991 962: Increase, Mucin production 943: Hypersecretion, Mucus Nov 29, 2016 Nov 29, 2016 None
1315 962: Increase, Mucin production 1251: Chronic, Mucus hypersecretion Nov 29, 2016 Aug 30, 2021 None
2859 962: Increase, Mucin production 1250: Decreased lung function Mar 15, 2023 Mar 16, 2023
1486 1374: Increase, mucosal blood flow 1380: Activate, mucosal defense Apr 17, 2017 Apr 17, 2017
1485 1373: Increase, mucous 1380: Activate, mucosal defense Apr 17, 2017 Apr 17, 2017
202 185: Increase, Mutations 336: Increase, Heritable mutations in offspring Nov 29, 2016 Nov 29, 2016
899 185: Increase, Mutations 885: Increase, Cancer Nov 29, 2016 Dec 3, 2016
1896 185: Increase, Mutations 1182: Increase, Cell Proliferation (Epithelial Cells) May 7, 2019 May 8, 2019
1978 185: Increase, Mutations 870: Increase, Cell Proliferation Aug 29, 2019 Mar 8, 2024
1984 185: Increase, Mutations 1556: Increase, lung cancer Aug 29, 2019 Jan 10, 2023
2609 185: Increase, Mutations 1980: Increase,miRNA levels Mar 22, 2022 Aug 27, 2023
894 876: Increase, Mutations in Critical Genes 872: Increase, Site of Contact Nasal Tumors Nov 29, 2016 Dec 1, 2016
1356 1272: Increase, Myofibroblast expansion 1274: Production of α-smooth muscle actin Feb 15, 2017 Feb 15, 2017 None
1443 1341: Increase, myosin light chain phosphorylation 1342: Increase, vascular smooth muscle contraction Apr 14, 2017 Apr 14, 2017
1874 1607: Increase, Necrosis 350: Increase, Mortality Mar 19, 2019 Mar 19, 2019 None
2122 1607: Increase, Necrosis 1777: Increase, Ovarian follicle breakdown May 8, 2020 May 8, 2020 None
2177 1607: Increase, Necrosis 1809: Increase, Tissue/organ damage Nov 2, 2020 Nov 2, 2020 None