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All KERs

Showing 2026 to 2050 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3439	1076: Increased, circulating estrogen levels	2251: Increased E2 availability	Nov 22, 2024	Nov 22, 2024	1 AOP 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
2270	961: Increased, Clearance of thyroxine from serum	281: T4 in serum, Decreased	Jan 26, 2021	Jan 26, 2021	7 AOPs 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
350	384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci	378: Tumorigenesis, Hepatocellular carcinoma	Nov 29, 2016	Dec 3, 2016	None
695	693: Increased, cyclic adenosine monophosphate	675: Reduced, Reproductive Success	Nov 29, 2016	Dec 3, 2016	None
696	693: Increased, cyclic adenosine monophosphate	694: Reduced, Meiotic prophase I/metaphase I transition, oocyte	Nov 29, 2016	Dec 3, 2016	1 AOP 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
3446	693: Increased, cyclic adenosine monophosphate	2289: RyR2 hyperphosphorylation	Nov 26, 2024	Nov 26, 2024	1 AOP 558: Phosphodiesterase inhibition leading to heart failure
484	458: Increased, De Novo FA synthesis	454: Increased, Triglyceride formation	Nov 29, 2016	Dec 3, 2016	None
512	458: Increased, De Novo FA synthesis	327: Accumulation, Fatty acid	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis
1607	458: Increased, De Novo FA synthesis	459: Increase, Liver steatosis	Jul 18, 2017	Jul 18, 2017	1 AOP 61: NFE2L2/FXR activation leading to hepatic steatosis
1155	1109: Increased, Deformed Wing Virus levels	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	1 AOP 179: Varroa mite infestation increases virus levels leading to colony loss/failure
2146	1790: Increased, Differentiation to Testis	1791: Increased, Male Biased Sex Ratio	Jun 15, 2020	Jan 3, 2023	2 AOPs 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation 376: Androgen receptor agonism leading to male-biased sex ratio
1966	1669: Increased, DNA damage and mutation	870: Increase, Cell Proliferation	Jul 3, 2019	Jul 3, 2019	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 451: Interaction with lung resident cell membrane components leads to lung cancer
2417	1669: Increased, DNA damage and mutation	1896: Genomic instability	Jul 6, 2021	Jul 6, 2021	1 AOP 409: Frustrated phagocytosis leads to malignant mesothelioma
2608	1669: Increased, DNA damage and mutation	155: Inadequate DNA repair	Mar 22, 2022	Aug 27, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
2728	1669: Increased, DNA damage and mutation	1554: Increase chromosomal aberrations	Aug 14, 2022	Aug 27, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
1366	1281: Increased, DNA Damage-Repair	1262: Apoptosis	Feb 15, 2017	Feb 15, 2017	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
3594	1281: Increased, DNA Damage-Repair	2354: Activation, Apoptosis signaling	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
1252	1192: Increased, Ductal Hyperplasia	1193: N/A, Breast Cancer	Nov 29, 2016	May 8, 2019	3 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1157	1110: Increased, Energetic demands and therefore metabolic stress	560: Abnormal, Foraging activity and behavior	Nov 29, 2016	Dec 3, 2016	1 AOP 183: Nosema infection increases energetic demands leading to colony loss/failure
3082	1363: Increased, epilepsy	350: Increase, Mortality	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
1250	1187: Increased, ER binding to DNA (classical pathway)	1182: Increase, Cell Proliferation (Epithelial Cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1296	1187: Increased, ER binding to DNA (classical pathway)	1239: Altered, Gene Expression	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1251	1188: Increased, ER binding to T.F. to DNA (non-classical pathway)	1182: Increase, Cell Proliferation (Epithelial Cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1297	1188: Increased, ER binding to T.F. to DNA (non-classical pathway)	1239: Altered, Gene Expression	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
3115	2205: Increased, essential element imbalance	1115: Increase, ROS	Jan 24, 2024	Aug 2, 2024	1 AOP 521: Essential element imbalance leads to reproductive failure via oxidative stress

Key Event Relationships (KERs)

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