Prototypical Stressors

Showing 151 to 175 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

107	Bifenthrin	Bifenthrin, CAS-RN: 82657-04-3, DTXSID9020160	None
474	BIO (6-bromoindirubin-3’-oxime)		410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
279	Bioflavonoids		202: Inhibitor binding to topoisomerase II leading to infant leukaemia
11	Bis(2-ethylhexyl) phthalate	Di(2-ethylhexyl) phthalate, CAS-RN: 117-81-7, DTXSID5020607	2 AOPs 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
665	Bis(2,4,6-trimethylphenyl)-lambda~2~-germane--selenium (1/1)	Bis(2,4,6-trimethylphenyl)-lambda~2~-germane--selenium (1/1), CAS-RN: 115385-04-1, DTXSID10556604	413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
467	Bisdiamine		2 AOPs 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
521	Bisphenol A	Bisphenol A, CAS-RN: 80-05-7, DTXSID7020182	4 AOPs 314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) 522: Estrogen antagonism leading to increased risk of autism-like behavior 535: Binding and activation of GPER leading to learning and memory impairments 554: β-adrenergic receptor agonists leading to arrhythmias.
775	Bixafen	Bixafen, CAS-RN: 581809-46-3, DTXSID6058134	3 AOPs 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
337	Bleomycin	Bleomycin, CAS-RN: 11056-06-7, DTXSID1030862	2 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 550: Increased LMNA gene mutation leading to heart failure
428	BMS 345541	BMS 345541, CAS-RN: 547757-23-3, DTXSID70203243	None
726	BMS-89453		436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
774	Boscalid	Boscalid, CAS-RN: 188425-85-6, DTXSID6034392	3 AOPs 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
138	Bromocriptine	Bromocriptine, CAS-RN: 25614-03-3, DTXSID1022687	None
853	Brusatol		615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
791	Bupivacaine		553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
12	Butyl 4-hydroxybenzoate	4-Hydroxybenzoic acid butyl ester, CAS-RN: 94-26-8, DTXSID3020209	None
568	butyl benzyl phthalate		None
687	Butylate	Butylate, CAS-RN: 2008-41-5, DTXSID7023936	None
561	Butylparaben	4-Hydroxybenzoic acid butyl ester, CAS-RN: 94-26-8, DTXSID3020209	None
341	Butyrate	Butyrate, CAS-RN: 461-55-2, DTXSID8040432	2 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 274: Histone deacetylase inhibition leads to impeded craniofacial development
335	Cadmium	Cadmium, CAS-RN: 7440-43-9, DTXSID1023940	10 AOPs 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 521: Essential element imbalance leads to reproductive failure via oxidative stress 550: Increased LMNA gene mutation leading to heart failure 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure 560: Inhibition of Funny current (If) leading to Arrhythmias 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
456	Cadmium chloride	Cadmium chloride, CAS-RN: 10108-64-2, DTXSID6020226	296: Oxidative DNA damage leading to chromosomal aberrations and mutations
380	Calcium channel blockers		261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
841	calcium ionophore		None
785	Camptothecin		550: Increased LMNA gene mutation leading to heart failure