Prototypical Stressors

Showing 151 to 175 of 853 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

428	BMS 345541	BMS 345541, CAS-RN: 547757-23-3, DTXSID70203243	None
726	BMS-89453		436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
774	Boscalid	Boscalid, CAS-RN: 188425-85-6, DTXSID6034392	3 AOPs 534: Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
138	Bromocriptine	Bromocriptine, CAS-RN: 25614-03-3, DTXSID1022687	None
853	Brusatol		615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
791	Bupivacaine		553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
12	Butyl 4-hydroxybenzoate	4-Hydroxybenzoic acid butyl ester, CAS-RN: 94-26-8, DTXSID3020209	None
568	butyl benzyl phthalate		None
687	Butylate	Butylate, CAS-RN: 2008-41-5, DTXSID7023936	None
561	Butylparaben	4-Hydroxybenzoic acid butyl ester, CAS-RN: 94-26-8, DTXSID3020209	None
341	Butyrate	Butyrate, CAS-RN: 461-55-2, DTXSID8040432	2 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 274: Histone deacetylase inhibition leads to impeded craniofacial development
335	Cadmium	Cadmium, CAS-RN: 7440-43-9, DTXSID1023940	9 AOPs 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 521: Essential element imbalance leads to reproductive failure via oxidative stress 550: Increased LMNA gene mutation leading to heart failure 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure 560: Inhibition of Funny current (If) leading to Arrhythmias 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
456	Cadmium chloride	Cadmium chloride, CAS-RN: 10108-64-2, DTXSID6020226	296: Oxidative DNA damage leading to chromosomal aberrations and mutations
380	Calcium channel blockers		261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
841	calcium ionophore		None
785	Camptothecin		550: Increased LMNA gene mutation leading to heart failure
691	Candesartan cilexetil	Candesartan cilexetil, CAS-RN: 145040-37-5, DTXSID5020239	None
597	Capta		None
594	Captafol	Captafol, CAS-RN: 2425-06-1, DTXSID4020242	360: Chitin synthase 1 inhibition leading to mortality
595	Captan	Captan, CAS-RN: 133-06-2, DTXSID9020243	360: Chitin synthase 1 inhibition leading to mortality
786	Carbamate pesticides		551: Increased Muscarinic M2 Receptor leading to Arrhythmia
92	Carbamazepine	Carbamazepine, CAS-RN: 298-46-4, DTXSID4022731	None
819	Carbaryl		559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
129	Carbendazim	Carbendazim, CAS-RN: 10605-21-7, DTXSID4024729	None
545	Carbenoxolone	Carbenoxolone, CAS-RN: 5697-56-3, DTXSID4022733	348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory