AOPs

OECD View API
Searches both title and fulltext content
Takes you to the requested AOP
Clear Search Terms Clears search terms and filters

Showing 501 to 525 of 574 AOPs

Clear Table Filters
ID Title Point of Contact License MIE AO OECD Status OECD Project
562 HCN Channel Inhibition leading to Arrhythmias Young Jun Kim All rights reserved 2295: HCN Channel Inhibition 1106: Occurrence, cardiac arrhythmia
563 Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis Sapana Kushwaha All rights reserved 18: Activation, AhR 2305: Premature ovarian Insufficiency
564 DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. lihua Yang BY-SA 1541: Mitochondrial Complex I inhibition
565 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha Martina Panzarea All rights reserved 2250: 17β-Hydroxysteroid dehydrogenase 2, inhibition None
566 Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation Martina Panzarea All rights reserved None 2306: Persistent vaginal cornification
567 Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition Li Xie BY-SA 2307: Binding of plastoquinone B (QB) within D1 protein of Photosystem II 360: Decrease, Population growth rate
568 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding John Frisch BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1016: Inhibition, Feeding
569 Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway Huimin Ma All rights reserved 2309: Decreased DNA methylation of FAM50B/PTCHD3 2121: decreased, Intellectual Quotient
570 Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA None 2082: Hypospadias, increased
571 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 2082: Hypospadias, increased
572 BMP4 Suppression Disrupting Cytoskeletal Remodeling Leading to Neural Tube Closure Defects Job Berkhout All rights reserved None None
573 Inhibition, cytochrome oxidase leads to Increased, pulmonary edema John Frisch BY-SA 1840: Inhibition, cytochrome oxidase 2316: Increased, pulmonary edema
574 Inhibition, cytochrome oxidase leads to Loss of olfactory function John Frisch BY-SA 1840: Inhibition, cytochrome oxidase 2317: Loss of olfactory function
575 Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring Terje Svingen BY-SA None 1786: Nipple retention (NR), increased
576 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 1786: Nipple retention (NR), increased
577 AhR activation leading to endometriosis Léna CAUDAL BY-SA 18: Activation, AhR None
578 AhR activation leading to cancer progression via immunosuppression Léo SPORTES-MILOT BY-SA 18: Activation, AhR 1971: Increased, tumor growth
579 Transthyretin disruption in developing fish leading to projected decline in fish population Adriana Webb BY-SA None None
580 Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index Théo Jamay All rights reserved 2331: Activation, Mineralocorticoid Receptor 2335: Increase, body mass index
581 Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease Marie-Gabrielle Zurich All rights reserved 122: Increase, Glucocorticoid receptor activation 402: Cognitive function, decreased
582 Inhibition of EphA2 phosphorylation leads to liver damage via the ERK/ MDM2/p53 axis Peihua Luo All rights reserved None None
583 Vascular endothelial HER2 inhibition disrupts cardiomyocyte calcium homeostasis via EGFR/STAT3/PTX3 axis leading to cardiac contractile dysfunction Peihua Luo All rights reserved None None
584 SQLE accumulation leads to hepatotoxicity via cholesterol/sphingolipid metabolic disturbance and lysosomal damage Peihua Luo All rights reserved None None
585 AKT Inhibition blocks the autophagy flow through the PRKAA/AMPK pathway and leads to cardiotoxicity Peihua Luo All rights reserved None None
586 The increasing accumulation of HMGB1 in the nucleus causes cardiomyocyte death via HMGB1/HSPB1/CCN2 pathway Peihua Luo All rights reserved None None