AOPs

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Showing 251 to 275 of 579 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
387 Deposition of ionising energy leading to population decline via mitochondrial dysfunction Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
386 Deposition of ionizing energy leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
385 Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation Julija Filipovska BY-SA 1739: Binding to ACE2 None
384 Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Young Jun Kim BY-SA 1853: Hyperactivation of ACE/Ang-II/AT1R axis 1603: Chronic kidney disease
383 Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis Young Jun Kim BY-SA 1740: Induced dysregulation of ACE2 344: Increase, Liver fibrosis Under Development 1.96
382 Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis Young Jun Kim BY-SA 1851: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) 1276: Lung fibrosis Under Development 1.96
381 Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia Young Jun Kim BY-SA 1739: Binding to ACE2 1850: dysgeusia Under Development 1.96
379 Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation Shihori Tanabe All rights reserved 1739: Binding to ACE2 1846: Thrombosis and Disseminated Intravascular Coagulation Under Development 1.96
378 Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Gillina Bezemer BY-SA 1848: Toll Like Receptor (TLR) Dysregulation None
377 Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) Gillina Bezemer BY-SA 1842: Prolonged TLR9 activation
376 Androgen receptor agonism leading to male-biased sex ratio Dan Villeneuve BY-SA 25: Agonism, Androgen receptor 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
375 test AOP Kevin Crofton BY-SA None None
374 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis Anna Price All rights reserved 1739: Binding to ACE2 1841: Encephalitis Under Development 1.96
373 Mitochondrial dysfunction to metabolic diseases Chander K. Negi BY-SA None None
372 Androgen receptor antagonism leading to testicular cancer Chander K. Negi BY-SA 26: Antagonism, Androgen receptor 1839: Testicular Cancer
371 Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone You Song BY-SA None None
370 Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis You Song BY-SA None None
369 Photosystem II antagonism leading to growth inhibition via oxidative damage You Song BY-SA None None
368 Cytochrome oxidase inhibition leading to increased nasal lesions Katy Goyak BY-SA 1840: Inhibition, cytochrome oxidase 2312: Increased, nasal lesions
367 Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1831: Binding, Thyroid binding globulin in serum 1101: Altered, Amphibian metamorphosis
366 Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 957: Binding, Transthyretin in serum 1101: Altered, Amphibian metamorphosis
365 Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning Lucia Vergauwen All rights reserved 279: Thyroperoxidase, Inhibition Under Development 1.35
364 Thyroperoxidase inhibition leading to altered visual function via decreased eye size Lucia Vergauwen All rights reserved 279: Thyroperoxidase, Inhibition Under Development 1.35
363 Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure Lucia Vergauwen BY-SA 279: Thyroperoxidase, Inhibition Under Review 1.35
362 Immune mediated hepatitis Jung-Hwa Oh BY-SA 1814: benzoquinone imine and acylglucuronide metabolites 1820: Immune mediated hepatitis