AOPs

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Showing 251 to 275 of 595 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
405 Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function SAROJ AMAR BY-SA 12: Acetylcholinesterase (AchE) Inhibition 402: Cognitive function, decreased
404 Metabolic Syndrome leading to Toll Like Receptor dysregulation Gillina Bezemer BY-SA None None
403 combined unhealthy lifestyle factors leading to metabolic syndrome Gillina Bezemer BY-SA None None
402 Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain Katherine (Katie) O'Shaughnessy BY-SA 279: Thyroperoxidase, Inhibition
401 G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects Fei Li BY-SA 2029: protein-coupled estrogen receptor 1 (GPER) activation 1489: Increase, Steatohepatitis
400 Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility Terje Svingen BY-SA 1887: Inhibition of CYP26B1 activity 406: decreased, Fertility
399 Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) Vid Modic BY-SA 1884: Inhibition of Fyna
398 Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia Terje Svingen BY-SA 1880: Decreased, ALDH1A (RALDH) enzyme activity 406: decreased, Fertility Under Development 1.97
397 Bulky DNA adducts leading to mutations Carole Yauk BY-SA 1879: Bulky DNA adducts, increase 185: Increase, Mutations Under Development 1.11
396 Deposition of ionizing energy leads to population decline via impaired meiosis Erica Maremonti BY-SA 1550: Deposition of Ionizing Energy
395 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) Magda Sachana BY-SA 1739: Binding to ACE2 1875: Cerebrovascular disease (stroke) Under Development 1.96
394 SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) Sandra Coecke BY-SA 1739: Binding to ACE2 1873: impaired olfactory function (anosmia) Under Development 1.96
393 AOP for thyroid disorder caused by triphenyl phosphate via TRĪ² activation Fei Li BY-SA 1158: Increased, Hepatic thyroid hormone uptake/transport None
392 Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation Penny Nymark BY-SA 1868: Hyperinflammation Under Development 1.96
389 Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen BY-SA 1865: Increase, Oxygen-evolving complex damage
388 Deposition of ionising energy leading to population decline via programmed cell death Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
387 Deposition of ionising energy leading to population decline via mitochondrial dysfunction Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
386 Deposition of ionizing energy leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
385 Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation Julija Filipovska BY-SA 1739: Binding to ACE2 None
384 Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Young Jun Kim BY-SA 1853: Hyperactivation of ACE/Ang-II/AT1R axis 1603: Chronic kidney disease
383 Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis Young Jun Kim BY-SA 1740: Induced dysregulation of ACE2 344: Increase, Liver fibrosis Under Development 1.96
382 Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis Young Jun Kim BY-SA 1851: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) 1276: Lung fibrosis Under Development 1.96
381 Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia Young Jun Kim BY-SA 1739: Binding to ACE2 1850: dysgeusia Under Development 1.96
379 Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation Shihori Tanabe All rights reserved 1739: Binding to ACE2 1846: Thrombosis and Disseminated Intravascular Coagulation Under Development 1.96
378 Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Gillina Bezemer BY-SA 1848: Toll Like Receptor (TLR) Dysregulation None