AOPs

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Showing 276 to 300 of 595 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
377 Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) Gillina Bezemer BY-SA 1842: Prolonged TLR9 activation
376 Androgen receptor agonism leading to male-biased sex ratio Dan Villeneuve BY-SA 25: Agonism, Androgen receptor 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
375 test AOP Kevin Crofton BY-SA None None
374 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis Anna Price BY-SA 1739: Binding to ACE2 1841: Encephalitis Under Development 1.96
373 Mitochondrial dysfunction to metabolic diseases Chander K. Negi BY-SA None None
372 Androgen receptor antagonism leading to testicular cancer Chander K. Negi BY-SA 26: Antagonism, Androgen receptor 1839: Testicular Cancer
371 Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone You Song BY-SA None None
370 Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis You Song BY-SA None None
369 Photosystem II antagonism leading to growth inhibition via oxidative damage You Song BY-SA None None
368 Cytochrome oxidase inhibition leading to increased nasal lesions Katy Goyak BY-SA 1840: Inhibition, cytochrome oxidase 2312: Increased, nasal lesions
367 Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1831: Binding, Thyroid binding globulin in serum 1101: Altered, Amphibian metamorphosis
366 Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 957: Binding, Transthyretin in serum 1101: Altered, Amphibian metamorphosis
365 Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning Lucia Vergauwen All rights reserved 279: Thyroperoxidase, Inhibition Under Development 1.35
364 Thyroperoxidase inhibition leading to altered visual function via decreased eye size Lucia Vergauwen All rights reserved 279: Thyroperoxidase, Inhibition Under Development 1.35
363 Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure Lucia Vergauwen BY-SA 279: Thyroperoxidase, Inhibition Under Review 1.35
362 Immune mediated hepatitis Jung-Hwa Oh BY-SA 1814: benzoquinone imine and acylglucuronide metabolites 1820: Immune mediated hepatitis
361 Sulfonylureareceptor binding leading to mortality Simon Schmid BY-SA 1525: Increase, Sulfonylurea receptor binding 350: Increase, Mortality Under Development 1.94
360 Chitin synthase 1 inhibition leading to mortality Simon Schmid BY-SA 1522: Inhibition, Chitin synthase 1 350: Increase, Mortality WPHA/WNT Endorsed 1.94
359 Chitobiase inhibition leading to mortality Simon Schmid BY-SA 1807: Inhibition, Chitobiase 350: Increase, Mortality Under Development 1.94
358 Chitinase inhibition leading to mortality Simon Schmid BY-SA 1806: Inhibition, Chitinase 350: Increase, Mortality Under Development 1.94
349 Inhibition of 11β-hydroxylase leading to decresed population trajectory Young Jun Kim BY-SA 1796: 11β-hydroxylase inhibition 360: Decrease, Population growth rate Under Development 1.93
348 Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory Young Jun Kim BY-SA 1799: Inhibition of 11β-HSD 360: Decrease, Population growth rate Under Development 1.93
347 Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis Seokjoo Yoon BY-SA 1458: Pulmonary fibrosis
346 Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Kelvin Santana Rodriguez BY-SA 36: Inhibition, Aromatase 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
345 Androgen receptor (AR) antagonism leading to decreased fertility in females Terje Svingen BY-SA 26: Antagonism, Androgen receptor Under Development 1.109