AOPs

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Showing 126 to 150 of 589 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
524 Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals Antonio Fernandez Dumont BY-SA 2257: Celiac disease Under Review 1.98
523 Retinoic acid receptor agonism during neurodevelopment leading to microcephaly Diana Lupu Open for adoption 2201: Agonism, Retinoic acid receptor 1978: Increase risk, microcephaly
522 Estrogen antagonism leading to increased risk of autism-like behavior Kanglong Cui Open for adoption 112: Antagonism, Estrogen receptor 2209: autism-like behavior
521 Essential element imbalance leads to reproductive failure via oxidative stress Travis Karschnik BY-SA 2205: Increased, essential element imbalance 2147: Decreased, Viable Offspring
520 Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory Diana Lupu Open for adoption 2201: Agonism, Retinoic acid receptor 341: Impairment, Learning and memory
519 Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality Young Jun Kim Open for adoption 2282: Cardiac ion channels blockade 1929: Increased incidence of cardiovascular morbidity and mortality in the general population
518 Liver X Receptor (LXR) activation leads to liver steatosis John Frisch BY-SA 167: Activation, LXR 459: Increase, Liver steatosis
517 Pregnane X Receptor (PXR) activation leads to liver steatosis John Frisch BY-SA 239: Activation, Pregnane-X receptor, NR1I2 459: Increase, Liver steatosis
516 Na+ /K+ -ATPase inhibition leading to hypertension Michelle Angrish BY-SA 1562: Decreased Na/K ATPase activity 952: Hypertension
515 An overview of adverse outcome pathway linked between PM2.5 exposure and congenital heart defects Liang Chen BY-SA None None
514 PLK1 Activation leading to hepatocyte apoptosis-associate liver injury via autophagy-mediated excessive COX6A1 degradation and impaired function of mitochondrial respiratory chain complex IV Hui Li BY-SA None None
513 Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway John Frisch BY-SA 1115: Increase, Reactive oxygen species 885: Increase, Cancer
512 Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level Ana-Andreea Cioca BY-SA None None
511 The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects Yanhong Wei BY-SA 1115: Increase, Reactive oxygen species 2161: Increase, Vascular disrupting effects
510 Demethylation of PPAR promotor leading to vascular disrupting effects Yanhong Wei BY-SA 228: peroxisome proliferator activated receptor promoter demethylation 2161: Increase, Vascular disrupting effects
509 Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction Yanhong Wei BY-SA 1417: NFE2/Nrf2 repression 2161: Increase, Vascular disrupting effects
508 Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway Yanhong Wei BY-SA 1417: NFE2/Nrf2 repression 2161: Increase, Vascular disrupting effects
507 Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway Yanhong Wei BY-SA 1417: NFE2/Nrf2 repression 2161: Increase, Vascular disrupting effects
506 Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation Jessica Resnick All rights reserved 2158: Influenza A Virus (IAV) binds sialic acid glycan receptor 2194: Influenza A Virus (IAV) shedding and transmission
505 Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway John Frisch BY-SA 1115: Increase, Reactive oxygen species 885: Increase, Cancer
504 SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level Martina Panzarea BY-SA 2155: Inhibition of Sulfotransferase E1 (SULT1E1) 1065: Activation, estrogen receptor alpha
503 Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation Barbara Viviani BY-SA 1065: Activation, estrogen receptor alpha 2154: Uterine adenocarcinoma (endometrioid adenocarcinoma Type I) Under Review 1.100
502 Decrease, cholesterol synthesis leads to orofacial clefting Jacob Reynolds BY-SA None 2042: Increase, Orofacial clefting Under Development 1.101
501 Excessive iron accumulation leading to neurological disorders Young Jun Kim Open for adoption 2149: Increased intracelluar Iron accumulation 2150: Neurological disorder
500 Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis Travis Karschnik BY-SA 2146: Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 341: Impairment, Learning and memory