AOPs

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Showing 126 to 150 of 579 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
514 PLK1 Activation leading to hepatocyte apoptosis-associate liver injury via autophagy-mediated excessive COX6A1 degradation and impaired function of mitochondrial respiratory chain complex IV Hui Li All rights reserved None None
513 Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway John Frisch BY-SA 1115: Increase, Reactive oxygen species 885: Increase, Cancer
512 Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level Ana-Andreea Cioca All rights reserved None None
511 The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects Yanhong Wei All rights reserved 1115: Increase, Reactive oxygen species 2161: Increase, Vascular disrupting effects
510 Demethylation of PPAR promotor leading to vascular disrupting effects Yanhong Wei All rights reserved 228: peroxisome proliferator activated receptor promoter demethylation 2161: Increase, Vascular disrupting effects
509 Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction Yanhong Wei All rights reserved 1417: NFE2/Nrf2 repression 2161: Increase, Vascular disrupting effects
508 Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway Yanhong Wei All rights reserved 1417: NFE2/Nrf2 repression 2161: Increase, Vascular disrupting effects
507 Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway Yanhong Wei All rights reserved 1417: NFE2/Nrf2 repression 2161: Increase, Vascular disrupting effects
506 Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation Jessica Resnick All rights reserved 2158: Influenza A Virus (IAV) binds sialic acid glycan receptor 2194: Influenza A Virus (IAV) shedding and transmission
505 Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway John Frisch BY-SA 1115: Increase, Reactive oxygen species 885: Increase, Cancer
504 SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level Martina Panzarea All rights reserved 2155: Inhibition of Sulfotransferase E1 (SULT1E1) 1065: Activation, estrogen receptor alpha
503 Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation Barbara Viviani BY-SA 1065: Activation, estrogen receptor alpha 2154: Uterine adenocarcinoma (endometrioid adenocarcinoma Type I) Under Review 1.100
502 Decrease, cholesterol synthesis leads to orofacial clefting Jacob Reynolds All rights reserved None 2042: Increase, Orofacial clefting Under Development 1.101
501 Excessive iron accumulation leading to neurological disorders Young Jun Kim Open for adoption 2149: Increased intracelluar Iron accumulation 2150: Neurological disorder
500 Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis Travis Karschnik All rights reserved 2146: Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 341: Impairment, Learning and memory
499 Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release Travis Karschnik All rights reserved 2146: Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 341: Impairment, Learning and memory
498 Increased LCN2/iron complex leading to neurological disorders Young Jun Kim Open for adoption 2148: Increased LCN2/iron complex binds to SLC22A17 receptor in neuron 2150: Neurological disorder
497 ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome Min Ji Kim All rights reserved 2126: Estrogen receptor alpha inactivation
496 Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） Hongling Liu BY-SA 25: Agonism, Androgen receptor 442: Decreased, Population trajectory
495 Androgen receptor activation leading to prostate cancer Jianxiang Li All rights reserved 25: Agonism, Androgen receptor 2135: Prostate cancer
494 AhR activation leading to liver fibrosis Xavier COUMOUL BY-SA 18: Activation, AhR 344: Increase, Liver fibrosis
493 ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity Min Ji Kim All rights reserved 2126: Estrogen receptor alpha inactivation 2129: Metabolically unhealthy Obesity
492 Glutathione conjugation leading to reproductive dysfunction via oxidative stress Leonardo Vieira All rights reserved 2131: Conjugation, GSH 406: decreased, Fertility
491 Decrease, GLI1/2 target gene expression leads to orofacial clefting Jacob Reynolds All rights reserved 2040: Decrease, GLI1/2 target gene expression 2042: Increase, Orofacial clefting Under Development 1.101
490 Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms Karine Audouze All rights reserved