AOPs

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Showing 151 to 175 of 595 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
505 Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway John Frisch BY-SA 1115: Increase, Reactive oxygen species 885: Increase, Cancer
504 SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level Martina Panzarea BY-SA 2155: Inhibition of Sulfotransferase E1 (SULT1E1) 1065: Activation, estrogen receptor alpha
503 Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation Barbara Viviani BY-SA 1065: Activation, estrogen receptor alpha 2154: Uterine adenocarcinoma (endometrioid adenocarcinoma Type I) Under Review 1.100
502 Decrease, cholesterol synthesis leads to orofacial clefting Jacob Reynolds BY-SA None 2042: Increase, Orofacial clefting Under Development 1.101
501 Excessive iron accumulation leading to neurological disorders Young Jun Kim Open for adoption 2149: Increased intracelluar Iron accumulation 2150: Neurological disorder
500 Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis Travis Karschnik BY-SA 2146: Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 341: Impairment, Learning and memory
499 Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release Travis Karschnik BY-SA 2146: Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 341: Impairment, Learning and memory
498 Increased LCN2/iron complex leading to neurological disorders Young Jun Kim Open for adoption 2148: Increased LCN2/iron complex binds to SLC22A17 receptor in neuron 2150: Neurological disorder
497 ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome Min Ji Kim BY-SA 2126: Estrogen receptor alpha inactivation
496 Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） Hongling Liu BY-SA 25: Agonism, Androgen receptor 442: Decreased, Population trajectory
495 Androgen receptor activation leading to prostate cancer Jianxiang Li BY-SA 25: Agonism, Androgen receptor 2135: Prostate cancer
494 AhR activation leading to liver fibrosis Xavier COUMOUL BY-SA 18: Activation, AhR 344: Increase, Liver fibrosis
493 ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity Min Ji Kim BY-SA 2126: Estrogen receptor alpha inactivation 2129: Metabolically unhealthy Obesity
492 Glutathione conjugation leading to reproductive dysfunction via oxidative stress Leonardo Vieira BY-SA 2131: Conjugation, GSH 406: decreased, Fertility
491 Decrease, GLI1/2 target gene expression leads to orofacial clefting Jacob Reynolds BY-SA 2040: Decrease, GLI1/2 target gene expression 2042: Increase, Orofacial clefting Under Development 1.101
490 Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms Karine Audouze BY-SA
489 Inhibition of voltage-gated sodium channels leading to decreased cognition Lidwina Gerner BY-SA 1353: Binding to voltage-gated sodium channel 402: Cognitive function, decreased
488 Increased reactive oxygen species production leading to decreased cognitive function Eliska Kuchovska BY-SA 1115: Increase, Reactive oxygen species 402: Cognitive function, decreased
487 Unknown MIE altering cholesterol metabolism leading to decreased cognition Eliska Kuchovska BY-SA 1114: Unknown, MIE 402: Cognitive function, decreased
486 Binding to the extracellular protein laminin leading to decreased cognitive function Eliska Kuchovska BY-SA 2109: Binding, extracellular matrix protein laminin 402: Cognitive function, decreased
485 Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition Eliska Kuchovska BY-SA 1656: Antagonism, Thyroid Receptor 402: Cognitive function, decreased
484 Bisphenol A analogs induce cellular dysfunction in human trophoblast cells in a thyroid hormone receptor-dependent manner: in silico and in vitro analyses Xiaoyun Wu BY-SA None None
483 Deposition of Energy Leading to Learning and Memory Impairment Vinita Chauhan BY-SA 1686: Deposition of Energy 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.89
482 Deposition of energy leading to occurrence of bone loss Vinita Chauhan BY-SA 1686: Deposition of Energy 2091: Occurrence, Bone Loss WPHA/WNT Endorsed 1.89
481 AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. Hailin Xu BY-SA 1115: Increase, Reactive oxygen species