AOPs

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Showing 151 to 175 of 579 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
489 Inhibition of voltage-gated sodium channels leading to decreased cognition Lidwina Gerner BY-SA 1353: Binding to voltage-gated sodium channel 402: Cognitive function, decreased
488 Increased reactive oxygen species production leading to decreased cognitive function Eliska Kuchovska BY-SA 1115: Increase, Reactive oxygen species 402: Cognitive function, decreased
487 Unknown MIE altering cholesterol metabolism leading to decreased cognition Eliska Kuchovska BY-SA 1114: Unknown, MIE 402: Cognitive function, decreased
486 Binding to the extracellular protein laminin leading to decreased cognitive function Eliska Kuchovska BY-SA 2109: Binding, extracellular matrix protein laminin 402: Cognitive function, decreased
485 Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition Eliska Kuchovska BY-SA 1656: Antagonism, Thyroid Receptor 402: Cognitive function, decreased
484 Bisphenol A analogs induce cellular dysfunction in human trophoblast cells in a thyroid hormone receptor-dependent manner: in silico and in vitro analyses Xiaoyun Wu BY-SA None None
483 Deposition of Energy Leading to Learning and Memory Impairment Vinita Chauhan BY-SA 1686: Deposition of Energy 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.89
482 Deposition of energy leading to occurrence of bone loss Vinita Chauhan BY-SA 1686: Deposition of Energy 2091: Occurrence, Bone Loss WPHA/WNT Endorsed 1.89
481 AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. Hailin Xu BY-SA 1115: Increase, Reactive oxygen species
480 Mitochondrial complexes inhibition leading to heart failure via decreased ATP production Alexandra Schaffert BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 2215: Decrease Left Ventricular function Under Development 1.102
479 Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress Sivakumar Murugadoss BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 2215: Decrease Left Ventricular function Under Development 1.102
478 Deposition of energy leading to occurrence of cataracts Vinita Chauhan BY-SA 1686: Deposition of Energy 2083: Occurrence of Cataracts WPHA/WNT Endorsed 1.89
477 Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 2082: Hypospadias, increased
476 Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity Yue Zhang All rights reserved
475 Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons Shihori Tanabe All rights reserved 875: Binding of agonist, Ionotropic glutamate receptors 341: Impairment, Learning and memory Under Development 1.107
474 Succinate dehydrogenase inactivation leads to cancer by promoting EMT Sylvie Bortoli BY-SA 2118: Succinate dehydrogenase, inhibited 885: Increase, Cancer Under Development 1.106
473 Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin Danielle Beaton BY-SA 1686: Deposition of Energy
472 DNA adduct formation leading to kidney failure Manoe Janssen BY-SA 373: Formation, Pro-mutagenic DNA Adducts 759: Increased, Kidney Failure
471 Neuron defect induced early behavioral change Woo-Keun Kim BY-SA 2195: Increase, CNS Neural cell death
470 Deposition of energy leads to abnormal vascular remodeling Vinita Chauhan BY-SA 1686: Deposition of Energy 2069: Occurrence, Abnormal Vascular Remodeling WPHA/WNT Endorsed 1.89
469 Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population Ruiyang Ding BY-SA None None
468 Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) Laure-Alix Clerbaux BY-SA 1739: Binding to ACE2 1868: Hyperinflammation
467 Knickkopf leading to mortality Donggon Yoo BY-SA 2058: Decrease, 20-hydroxyecdysone None
466 Doda decarboxylase leading to mortality Donggon Yoo BY-SA 2051: Decrease, Tyrosine None
465 Alcohol dehydrogenase leading to reproductive dysfunction Donggon Yoo BY-SA 2045: Increase, Alcohol dehydrogenase None