AOP-Wiki

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All Key Events

Showing 951 to 975 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1443	Atherosclerosis Short Name Atherosclerosis	1	Individual	Jun 29, 2017	Dec 18, 2023	237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
1442	Foam cell formation Short Name Foam cell formation	0	Organ	Jun 29, 2017	Jun 29, 2017	462: Activation of reactive oxygen species leading the atherosclerosis
1441	Increased systemic total cholesterol pool Short Name Systemic cholesterol increased	0	Organ	Jun 29, 2017	Jun 29, 2017	None
1440	Formation of HDL-SAA Short Name HDL-SAA formation	0	Cellular	Jun 29, 2017	Jun 29, 2017	None
1439	Systemic acute phase response Short Name Systemic acute phase response	1	Organ	Jun 29, 2017	Dec 18, 2023	237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
1438	Transcription of genes encoding acute phase proteins, Increased Short Name	1	Organ	Jun 29, 2017	Dec 18, 2023	237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
1437	Sensing of the stressor by pulmonary cells Short Name Sensing of the stressor	0	Molecular	Jun 29, 2017	Jun 29, 2017	None
1436	neurogenic inflammation of sensory nerves Short Name neurogenic inflammation	0	Cellular	Jun 27, 2017	Jun 27, 2017	None
1435	Increased neurokinin A (NKA) by neuronal cells Short Name Increased NKA	1	Cellular	Jun 23, 2017	Sep 16, 2017	196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1434	Irritation of nasal mucosa inducing sneeze reflex Short Name Irritation induced sneezing	1	Tissue	Jun 23, 2017	Sep 16, 2017	196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1433	Increased CGRP, neuronal release of CGRP Short Name Increased CGRP	1	Cellular	Jun 23, 2017	Sep 16, 2017	196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1432	Anti-depressant Activity Short Name Anti-depressant Activity	0	Individual	Jun 23, 2017	Jun 23, 2017	2 AOPs 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
1431	Serotonin 1A Receptor Agonism Short Name Serotonin 1A Receptor Agonism	0	Molecular	Jun 23, 2017	Jun 23, 2017	2 AOPs 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
1430	Inhibition of neurotransmitter vesicle release Short Name Inhibition of neurotransmitter release	0	Cellular	Jun 23, 2017	Jun 27, 2023	2 AOPs 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
1429	Inhibition of N-type Ca ion channels Short Name Inhibition of Ca Channels	0	Cellular	Jun 23, 2017	Jun 23, 2017	2 AOPs 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
1428	Analgesia Short Name Analgesia	0	Individual	Jun 8, 2017	Jun 8, 2017	2 AOPs 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
1427	Opening of G protein gated inward rectifying K channels Short Name Opening of GIRK channels	0	Cellular	Jun 8, 2017	Jun 8, 2017	2 AOPs 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
1426	Release of G Proteins Short Name Release of G Proteins	0	Cellular	Jun 8, 2017	Jun 8, 2017	4 AOPs 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
1425	Mu Opioid Receptor Agonism Short Name Mu Opioid Receptor Agonism	0	Molecular	Jun 8, 2017	Jun 8, 2017	2 AOPs 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
1424	Reduced, fatty acid beta oxidation Short Name Reduced, fatty acid beta oxidation	0	Molecular	Jun 2, 2017	Jun 2, 2017	232: NFE2/Nrf2 repression to steatosis
1423	Reduced, HSD17B4 activity Short Name Reduced, HSD17B4 activity	0	Molecular	Jun 2, 2017	Jun 2, 2017	232: NFE2/Nrf2 repression to steatosis
1422	Reduced, PPARalpha Short Name Reduced, PPARalpha	0	Molecular	Jun 2, 2017	Jun 2, 2017	232: NFE2/Nrf2 repression to steatosis
1421	Activated, LXR Short Name Activated, LXR	0	Molecular	Jun 2, 2017	Jun 2, 2017	232: NFE2/Nrf2 repression to steatosis
1417	NFE2/Nrf2 repression Short Name NFE2/Nrf2 repression	0	Molecular	Jun 2, 2017	Jun 2, 2017	5 AOPs 232: NFE2/Nrf2 repression to steatosis 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
1416	Decreased, intracellular chloride Short Name Decreased, intracellular chloride	0	Cellular	Jun 2, 2017	Jun 2, 2017	231: presynaptic neuron 2 repression to epilepsy