AOP-Wiki

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All Key Events

Showing 476 to 500 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

858	Decreased, PPARalpha transactivation of gene expression Short Name	1	Molecular	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
859	Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	None
860	Decreased, Mitochondrial Fatty Acid Beta Oxidation Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	318: Glucocorticoid Receptor activation leading to hepatic steatosis
861	Decreased, Ketogenesis (production of ketone bodies) Short Name	1	Cellular	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
862	Not Increased, Circulating Ketone Bodies Short Name	2	Tissue	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
863	Increased, Catabolism of Muscle Protein Short Name Increased, Catabolism of Muscle Protein	1	Organ	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
864	Decreased, Body Weight Short Name Decreased, Body Weight	1	Individual	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
867	Decrease, Intracellular pH Short Name Decrease, Intracellular pH	1	Cellular	Nov 29, 2016	Sep 16, 2017	136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
868	Increase, Tissue Degeneration, Necrosis & Atrophy Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
869	Increase, Respiratory or Squamous Metaplasia Short Name	1	Tissue	Nov 29, 2016	Sep 29, 2017	136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
870	Increase, Cell Proliferation Short Name Increase, Cell Proliferation	2	Cellular	Nov 29, 2016	Dec 10, 2024	8 AOPs 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors 303: Frustrated phagocytosis-induced lung cancer 272: Deposition of energy leading to lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma 420: Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 451: Interaction with lung resident cell membrane components leads to lung cancer 478: Deposition of energy leading to occurrence of cataracts
872	Increase, Site of Contact Nasal Tumors Short Name Increase, Site of Contact Nasal Tumors	1	Organ	Nov 29, 2016	Sep 16, 2017	136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
875	Binding of agonist, Ionotropic glutamate receptors Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
876	Increase, Mutations in Critical Genes Short Name Increase, Mutations in Critical Genes	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
877	Inhibition, organic anion transporter 1 (OAT1) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
878	Inhibition, SREBP1c Short Name Inhibition, SREBP1c	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
879	Activation, MTTP Short Name Activation, MTTP	1	Cellular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
880	Increased, ApoB100 Short Name Increased, ApoB100	1	Tissue	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
881	Increased, Triglyceride Short Name Increased, Triglyceride	1	Cellular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
885	Increase, Cancer Short Name Increase, Cancer	1	Tissue	Nov 29, 2016	Aug 22, 2023	7 AOPs 141: Alkylation of DNA leading to cancer 2 139: Alkylation of DNA leading to cancer 1 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway 534: Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
887	Inhibition, NADH-ubiquinone oxidoreductase (complex I) Short Name	1	Cellular	Nov 29, 2016	Oct 3, 2025	3 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome 273: Mitochondrial complex inhibition leading to liver injury
888	Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) Short Name	1	Molecular	Nov 29, 2016	Mar 28, 2018	3 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome 273: Mitochondrial complex inhibition leading to liver injury
889	Proteostasis, impaired Short Name Proteostasis, impaired	1	Cellular	Nov 29, 2016	Oct 16, 2025	4 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 273: Mitochondrial complex inhibition leading to liver injury 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
890	Degeneration of dopaminergic neurons of the nigrostriatal pathway Short Name	1	Organ	Nov 29, 2016	Oct 1, 2025	6 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 471: Neuron defect induced early behavioral change 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits 588: Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits 589: Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
896	Parkinsonian motor deficits Short Name Parkinsonian motor deficits	1	Individual	Nov 29, 2016	Mar 12, 2018	7 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 471: Neuron defect induced early behavioral change 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits 588: Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits 589: Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons