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All KERs

Showing 776 to 800 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2753	2059: Decrease, knickkopf gene	2060: Decrease, Chitin laminar organization	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
2754	2059: Decrease, knickkopf gene	2061: Decrease, Prevent chitin degradation by chitinases	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
1671	1478: Decrease, Leaf cell mitosis	1479: Decrease, Leaf development	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1672	1479: Decrease, Leaf development	1480: Increase, Growth hormone	Oct 10, 2017	Oct 10, 2017	None
2283	1479: Decrease, Leaf development	1521: Decrease, Growth	Feb 16, 2021	Feb 16, 2021	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
2335	1479: Decrease, Leaf development	1863: Decrease, Reproduction	Apr 11, 2021	Apr 11, 2021	1 AOP 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
1666	1474: Decrease, Light harvest capacity	1475: Decrease, Photosynthesis	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
3061	2198: Decrease, mbp	352: N/A, Neurodegeneration	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
3643	2375: Decrease, Mis-timed EcR-responsive NR cascade	988: Decrease, Circulating ETH	Sep 29, 2025	Sep 29, 2025	1 AOP 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
3644	2375: Decrease, Mis-timed EcR-responsive NR cascade	1522: Inhibition, CHS-1	Sep 29, 2025	Sep 29, 2025	1 AOP 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
2094	1770: Decrease, MMP	1477: OXPHOS, decreased	Apr 30, 2020	Apr 30, 2020	2 AOPs 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 328: Excessive reactive oxygen species production leading to mortality (2)
2347	1770: Decrease, MMP	1864: Increase, Programmed cell death	Apr 11, 2021	Apr 11, 2021	None
3163	1770: Decrease, MMP	177: Increase, Mitochondrial dysfunction	Mar 14, 2024	Mar 14, 2024	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3613	1770: Decrease, MMP	40: Mitochondrial ATP production, decreased	Sep 2, 2025	Sep 2, 2025	1 AOP 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction
3657	2377: neural network formation	2231: Impaired locomotor function	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
3659	2377: neural network formation	341: Impairment, Learning and memory	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2758	2063: Decrease, New cuticle secretion	990: Increase, Incomplete ecdysis	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
559	572: Decrease, Number of worker bees	563: Death/Failure, Colony	Nov 29, 2016	Dec 3, 2016	2 AOPs 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
573	572: Decrease, Number of worker bees	568: impaired, Hive thermoregulation	Nov 29, 2016	Dec 3, 2016	2 AOPs 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
1470	1366: Decrease, Oogenesis	488: Decrease, Ovulation	Apr 15, 2017	Apr 15, 2017	None
1752	1366: Decrease, Oogenesis	328: Decrease, Fecundity	Jun 12, 2018	Jun 12, 2018	3 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3)
2586	1366: Decrease, Oogenesis	1863: Decrease, Reproduction	Mar 1, 2022	Mar 1, 2022	None
2588	1366: Decrease, Oogenesis	78: Reduction, Cumulative fecundity and spawning	Mar 1, 2022	Mar 1, 2022	4 AOPs 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
2114	1782: Decrease, Oogenesis (F3)	1781: Decrease, Fecundity (F3)	Apr 30, 2020	Apr 30, 2020	2 AOPs 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
544	488: Decrease, Ovulation	78: Reduction, Cumulative fecundity and spawning	Nov 29, 2016	Dec 3, 2016	None

Key Event Relationships (KERs)

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