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All KERs

Showing 776 to 800 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1752	1366: Decrease, Oogenesis	328: Decrease, Fecundity	Jun 12, 2018	Jun 12, 2018	3 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3)
2586	1366: Decrease, Oogenesis	1863: Decrease, Reproduction	Mar 1, 2022	Mar 1, 2022	None
2588	1366: Decrease, Oogenesis	78: Reduction, Cumulative fecundity and spawning	Mar 1, 2022	Mar 1, 2022	4 AOPs 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
2114	1782: Decrease, Oogenesis (F3)	1781: Decrease, Fecundity (F3)	Apr 30, 2020	Apr 30, 2020	2 AOPs 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
544	488: Decrease, Ovulation	78: Reduction, Cumulative fecundity and spawning	Nov 29, 2016	Dec 3, 2016	None
687	488: Decrease, Ovulation	675: Reduced, Reproductive Success	Nov 29, 2016	Dec 3, 2016	1 AOP 63: Cyclooxygenase inhibition leading to reproductive dysfunction
1471	488: Decrease, Ovulation	330: Decrease, Fertility	Apr 15, 2017	Apr 15, 2017	None
1753	488: Decrease, Ovulation	328: Decrease, Fecundity	Jun 12, 2018	Jun 12, 2018	None
1667	1475: Decrease, Photosynthesis	1476: Decrease, Glycolysis	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
2334	1475: Decrease, Photosynthesis	1472: Decrease, ATP production	Apr 11, 2021	Apr 11, 2021	2 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
2343	1475: Decrease, Photosynthesis	1808: Decrease, ATP synthase activity	Apr 11, 2021	Apr 11, 2021	None
3557	1475: Decrease, Photosynthesis	1545: Decrease in mitochondrial oxidative phosphorylation	Aug 5, 2025	Feb 23, 2026	1 AOP 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
3612	1475: Decrease, Photosynthesis	360: Decrease, Population growth rate	Sep 2, 2025	Sep 2, 2025	1 AOP 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
1737	1517: Decrease, PSII activity	1475: Decrease, Photosynthesis	May 24, 2018	May 24, 2018	None
2333	1862: Decrease, Photosystem II efficiency	1475: Decrease, Photosynthesis	Apr 11, 2021	Feb 23, 2026	3 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
2180	1810: Decrease, ATPase activity	1768: Increase, Abnormal osmoregulation	Nov 2, 2020	Nov 2, 2020	None
2756	2061: Decrease, Prevent chitin degradation by chitinases	2062: Weak, Procuticle protection	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
3585	2346: Downregulation, PCNA	1505: Cell cycle, disrupted	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
2336	1863: Decrease, Reproduction	360: Decrease, Population growth rate	Apr 11, 2021	Apr 11, 2021	5 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2556	1863: Decrease, Reproduction	442: Decreased, Population trajectory	Jan 21, 2022	Jan 21, 2022	1 AOP 435: Deposition of ionising energy leads to population decline via pollen abnormal
769	771: Decrease, Serum thyroid hormone (T4/T3)	753: Increase, Thyroid-stimulating hormone (TSH)	Nov 29, 2016	Dec 3, 2016	None
2735	2044: Decrease, SMO relocation	2028: Decrease, GLI1/2 translocation	Aug 23, 2022	Apr 2, 2025	1 AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting
2732	2043: Decrease, SHH second messenger production	1821: Decrease, Cell proliferation	Aug 23, 2022	Apr 3, 2025	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
2733	2043: Decrease, SHH second messenger production	1365: Increase, Apoptosis	Aug 23, 2022	Aug 23, 2022	None
2957	2043: Decrease, SHH second messenger production	1262: Apoptosis	Jun 29, 2023	Jun 29, 2023	1 AOP 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting

Key Event Relationships (KERs)

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