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All KERs

Showing 801 to 825 of 3119 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2180	1810: Decrease, ATPase activity	1768: Increase, Abnormal osmoregulation	Nov 2, 2020	Nov 2, 2020	None
2756	2061: Decrease, Prevent chitin degradation by chitinases	2062: Weak, Procuticle protection	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
3585	2346: Downregulation, PCNA	1505: Cell cycle, disrupted	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
2336	1863: Decrease, Reproduction	360: Decrease, Population growth rate	Apr 11, 2021	Apr 11, 2021	5 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2556	1863: Decrease, Reproduction	442: Decreased, Population trajectory	Jan 21, 2022	Jan 21, 2022	1 AOP 435: Deposition of ionising energy leads to population decline via pollen abnormal
769	771: Decrease, Serum thyroid hormone (T4/T3)	753: Increase, Thyroid-stimulating hormone (TSH)	Nov 29, 2016	Dec 3, 2016	None
2735	2044: Decrease, SMO relocation	2028: Decrease, GLI1/2 translocation	Aug 23, 2022	Apr 2, 2025	1 AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting
2732	2043: Decrease, SHH second messenger production	1821: Decrease, Cell proliferation	Aug 23, 2022	Apr 3, 2025	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
2733	2043: Decrease, SHH second messenger production	1365: Increase, Apoptosis	Aug 23, 2022	Aug 23, 2022	None
2957	2043: Decrease, SHH second messenger production	1262: Apoptosis	Jun 29, 2023	Jun 29, 2023	1 AOP 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
3060	2197: Decrease, sox10	352: N/A, Neurodegeneration	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
2685	2020: Decrease, sox9 expression	1559: Smaller and morphologically distorted facial cartilage structures	Jun 30, 2022	Oct 20, 2022	1 AOP 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
2691	2020: Decrease, sox9 expression	317: Altered, Cardiovascular development/function	Jun 30, 2022	Oct 20, 2022	1 AOP 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
436	266: Decrease, Steroidogenic acute regulatory protein (STAR)	447: Reduction, Cholesterol transport in mitochondria	Nov 29, 2016	Apr 8, 2025	1 AOP 18: PPARα activation in utero leading to impaired fertility in males
1547	1382: Decrease, surfactant	1405: Reduced, mucosal defense	Jun 2, 2017	Jun 2, 2017	1 AOP 229: Helicobacter pylori to gastric ulcer
1888	1622: Decrease, Transgenerational DNA methylation	1621: Increase, Gene expression	Apr 22, 2019	Apr 22, 2019	None
399	289: Decrease, Translocator protein (TSPO)	413: Reduction, Testosterone synthesis in Leydig cells	Nov 29, 2016	Dec 3, 2016	None
437	289: Decrease, Translocator protein (TSPO)	447: Reduction, Cholesterol transport in mitochondria	Nov 29, 2016	Dec 2, 2016	1 AOP 18: PPARα activation in utero leading to impaired fertility in males
2098	1772: Decrease, TAG	1771: Decrease, ATP pool	Apr 30, 2020	Apr 30, 2020	1 AOP 329: Excessive reactive oxygen species production leading to mortality (3)
2744	2051: Decrease, Tyrosine	2052: Decrease, dopa decarboxylase	Aug 28, 2022	Aug 28, 2022	1 AOP 466: Doda decarboxylase leading to mortality
3678	2384: Decrease, Vascular integrity	2383: Increase, Hemopericardium	Oct 30, 2025	Oct 30, 2025	2 AOPs 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
3216	450: Decrease, VLDL export capacity	459: Increase, Liver steatosis	May 9, 2024	May 9, 2024	1 AOP 57: AhR activation leading to hepatic steatosis
3515	2318: Decreased 3βHSD activity	1611: Reduction, androstenedione	Apr 8, 2025	Apr 8, 2025	None
3516	2318: Decreased 3βHSD activity	1693: Decreased, Progesterone levels	Apr 8, 2025	Apr 8, 2025	None
3497	2309: FAM50B/PTCHD3 methylation	2310: FAM50B/PTCHD3 expression	Mar 2, 2025	Mar 2, 2025	1 AOP 569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway

Key Event Relationships (KERs)

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