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All KERs

Showing 1326 to 1350 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1794	1552: DNA repair	1554: Increase chromosomal aberrations	Dec 19, 2018	Dec 19, 2018	None
1797	1555: Increase cell proliferation	1556: Increase, lung cancer	Dec 19, 2018	Dec 19, 2018	None
1796	1554: Increase chromosomal aberrations	1555: Increase cell proliferation	Dec 19, 2018	Dec 19, 2018	None
1801	1554: Increase chromosomal aberrations	1556: Increase, lung cancer	Dec 19, 2018	Dec 19, 2018	None
2729	1554: Increase chromosomal aberrations	1980: Increase,miRNA levels	Aug 14, 2022	Aug 27, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
2199	1633: Increase in inflammation	1820: hepatitis	Nov 2, 2020	Nov 2, 2020	1 AOP 362: Immune mediated hepatitis
2646	1633: Increase in inflammation	1097: Occurrence, renal proximal tubular necrosis	Apr 8, 2022	Apr 8, 2022	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3177	1633: Increase in inflammation	2119: Increase, Insulin resistance	Apr 9, 2024	Apr 9, 2024	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
1904	1632: Increase in RONS	1194: Increase, DNA Damage	May 7, 2019	May 8, 2019	3 AOPs 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
1906	1632: Increase in RONS	1492: Tissue resident cell activation	May 7, 2019	May 9, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
2331	1632: Increase in RONS	1861: D1 protein deactivation	Apr 11, 2021	Apr 11, 2021	None
2337	1632: Increase in RONS	1770: Decrease, MMP	Apr 11, 2021	Apr 11, 2021	None
2798	1632: Increase in RONS	2073: methemocyanin formation (decrease overall oxygen binding capacity)	Nov 16, 2022	Nov 16, 2022	1 AOP 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
3268	1632: Increase in RONS	1392: Increase, Oxidative Stress	Jul 4, 2024	Jul 4, 2024	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
3565	1632: Increase in RONS	1767: Increase, Protein oxidation	Aug 13, 2025	Aug 13, 2025	None
3566	1632: Increase in RONS	1445: Increase, LPO	Aug 13, 2025	Aug 13, 2025	None
3567	1632: Increase in RONS	1634: Increase, Oxidative DNA damage	Aug 13, 2025	Aug 13, 2025	None
1795	1553: Increase mutations	1555: Increase cell proliferation	Dec 19, 2018	Dec 19, 2018	None
1800	1553: Increase mutations	1556: Increase, lung cancer	Dec 19, 2018	Dec 19, 2018	None
1900	1553: Increase mutations	1182: Increase, Cell Proliferation (Epithelial Cells)	May 7, 2019	May 7, 2019	None
3237	1553: Increase mutations	885: Increase, Cancer	May 28, 2024	May 28, 2024	1 AOP 534: Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress
2023	1713: Increase of autoantibody production	1714: Exacerbation of SLE	Dec 29, 2019	Aug 14, 2020	1 AOP 314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
2022	1712: Increase of Th2 cells producing IL-4	1713: Increase of autoantibody production	Dec 29, 2019	Aug 14, 2020	1 AOP 314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
2799	2073: methemocyanin formation (decrease overall oxygen binding capacity)	2074: Decrease overall oxygen binding capacity (methemocyanin formation)	Nov 16, 2022	Nov 16, 2022	1 AOP 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2800	2073: methemocyanin formation (decrease overall oxygen binding capacity)	2075: Hemocyanin Bohr effect decrease	Nov 16, 2022	Nov 16, 2022	1 AOP 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin

Key Event Relationships (KERs)

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