Key Event Relationships (KERs)

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Showing 2876 to 2900 of 3164 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2134 227: Activation, PPARα 1756: Decreased, 11KT May 11, 2020 May 11, 2020 None
2252 227: Activation, PPARα 716: Increase, cell proliferation (hepatocytes) Dec 31, 2020 Dec 31, 2020
2253 227: Activation, PPARα 719: Increase, hepatocellular adenomas and carcinomas Dec 31, 2020 Dec 31, 2020
3675 227: Activation, PPARα 1312: Increase, Fatty acid β-oxidation Oct 30, 2025 Oct 30, 2025
3681 227: Activation, PPARα 948: reduced production, VEGF Oct 30, 2025 Oct 30, 2025
1418 1310: Activation, PI3K 1299: Activation, AKT Apr 13, 2017 Apr 13, 2017 None
1419 1310: Activation, PI3K 1302: Activation, L-FABP Apr 13, 2017 Apr 13, 2017 None
1420 1310: Activation, PI3K 1309: Activation, aPKC Apr 13, 2017 Apr 13, 2017 None
2719 2030: PARP1 177: Increase, Mitochondrial dysfunction Jul 28, 2022 Jul 28, 2022
532 478: Activation, NRF2 479: Activation, NR1H4 Nov 29, 2016 Dec 3, 2016
1406 478: Activation, NRF2 1304: Activation, FXR Apr 12, 2017 Apr 12, 2017 None
533 479: Activation, NR1H4 480: Activation, SHP Nov 29, 2016 Dec 3, 2016
534 479: Activation, NR1H4 227: Activation, PPARα Nov 29, 2016 Dec 3, 2016
581 559: Activation, Nicotinic acetylcholine receptor 177: Increase, Mitochondrial dysfunction Nov 29, 2016 Dec 3, 2016
658 559: Activation, Nicotinic acetylcholine receptor 663: Desensitization, Nicotinic acetylcholine receptor Nov 29, 2016 Jun 7, 2018
1146 559: Activation, Nicotinic acetylcholine receptor 341: Impairment, Learning and memory Nov 29, 2016 Dec 3, 2016
1147 559: Activation, Nicotinic acetylcholine receptor 560: Abnormal, Foraging activity and behavior Nov 29, 2016 Dec 3, 2016 None
1235 1174: Activation, NADPH Oxidase 209: Peptide Oxidation Nov 29, 2016 Dec 3, 2016 None
3511 1174: Activation, NADPH Oxidase 1115: Increase, ROS Apr 3, 2025 Apr 3, 2025
1392 1298: Activation, mTORC2 1299: Activation, AKT Apr 12, 2017 Apr 12, 2017 None
1393 1298: Activation, mTORC2 1300: Activation, mTORC1 Apr 12, 2017 Apr 12, 2017 None
1395 1300: Activation, mTORC1 1302: Activation, L-FABP Apr 12, 2017 Apr 12, 2017 None
1396 1300: Activation, mTORC1 1303: Activation, HSD17B4 Apr 12, 2017 Apr 12, 2017 None
1399 1300: Activation, mTORC1 1301: Activation, SREBP-1 Apr 12, 2017 Apr 12, 2017 None
3543 2331: Activation, MR 291: Accumulation, Triglyceride Jul 25, 2025 Jul 25, 2025