AOP-Wiki

API

All KERs

Showing 1326 to 1350 of 3119 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

564	341: Impairment, Learning and memory	564: Abnormal, Roll change within caste	Nov 29, 2016	Dec 3, 2016	2 AOPs 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
583	341: Impairment, Learning and memory	560: Abnormal, Foraging activity and behavior	Nov 29, 2016	Dec 3, 2016	4 AOPs 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
1644	341: Impairment, Learning and memory	635: Decreased, locomotion	Aug 11, 2017	Aug 11, 2017	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
2872	341: Impairment, Learning and memory	2121: decreased, IQ	Apr 4, 2023	Apr 4, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
1446	1328: Inactivated, 5-HTR	1329: Reduce expression, BDNF	Apr 14, 2017	Apr 14, 2017	3 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 225: Serotonin transporter activation to agitation 224: Serotonin transporter activation to depression
1511	1328: Inactivated, 5-HTR	1335: Reduced, BDNF	May 30, 2017	May 30, 2017	1 AOP 222: Mental stress to agitation
1353	1270: Inactivation of PPARγ	1271: Activation of TGF-β signaling	Feb 15, 2017	Feb 15, 2017	1 AOP 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
2156	1270: Inactivation of PPARγ	1283: Activation, TGF-beta pathway	Jul 9, 2020	Jul 9, 2020	1 AOP 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
164	155: Inadequate DNA repair	185: Increase, Mutations	Nov 29, 2016	Mar 8, 2024	8 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 141: Alkylation of DNA leading to cancer 2 139: Alkylation of DNA leading to cancer 1 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 397: Bulky DNA adducts leading to mutations 443: DNA damage and mutations leading to Metastatic Breast Cancer 478: Deposition of energy leading to occurrence of cataracts
1910	155: Inadequate DNA repair	1635: Increase, DNA strand breaks	May 19, 2019	Jan 9, 2023	3 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 322: Alkylation of DNA leading to reduced sperm count 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage
1912	155: Inadequate DNA repair	1636: Increase, Chromosomal aberrations	May 19, 2019	Dec 17, 2024	3 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
2817	155: Inadequate DNA repair	2083: Cataracts	Dec 18, 2022	Mar 11, 2024	1 AOP 478: Deposition of energy leading to occurrence of cataracts
1793	1552: DNA repair	1553: Increase mutations	Dec 19, 2018	Dec 19, 2018	None
1794	1552: DNA repair	1554: Increase chromosomal aberrations	Dec 19, 2018	Dec 19, 2018	None
1797	1555: Increase cell proliferation	1556: Increase, lung cancer	Dec 19, 2018	Dec 19, 2018	None
1796	1554: Increase chromosomal aberrations	1555: Increase cell proliferation	Dec 19, 2018	Dec 19, 2018	None
1801	1554: Increase chromosomal aberrations	1556: Increase, lung cancer	Dec 19, 2018	Dec 19, 2018	None
2729	1554: Increase chromosomal aberrations	1980: Increase,miRNA levels	Aug 14, 2022	Aug 27, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
2199	1633: Increase in inflammation	1820: hepatitis	Nov 2, 2020	Nov 2, 2020	1 AOP 362: Immune mediated hepatitis
2646	1633: Increase in inflammation	1097: Occurrence, renal proximal tubular necrosis	Apr 8, 2022	Apr 8, 2022	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3177	1633: Increase in inflammation	2119: Increase, Insulin resistance	Apr 9, 2024	Apr 9, 2024	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
1904	1632: Increase in RONS	1194: Increase, DNA Damage	May 7, 2019	May 8, 2019	3 AOPs 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
1906	1632: Increase in RONS	1492: Tissue resident cell activation	May 7, 2019	May 9, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
2331	1632: Increase in RONS	1861: D1 protein deactivation	Apr 11, 2021	Apr 11, 2021	None
2337	1632: Increase in RONS	1770: Decrease, MMP	Apr 11, 2021	Apr 11, 2021	None

Key Event Relationships (KERs)

All KERs