Prototypical Stressors

Showing 826 to 850 of 853 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

131	Vincristine	Vincristine, CAS-RN: 57-22-7, DTXSID1032278	None
153	Vinyl acetate	Vinyl acetate, CAS-RN: 108-05-4, DTXSID3021431	136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
378	Virus		2 AOPs 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
746	Vismodegib	Vismodegib, CAS-RN: 879085-55-9, DTXSID40236689	460: Antagonism of Smoothened receptor leading to orofacial clefting
732	Vitamin A		436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
291	Voriconazole	Voriconazole, CAS-RN: 137234-62-9, DTXSID5046485	None
195	Warfarin	Warfarin, CAS-RN: 81-81-2, DTXSID5023742	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
739	welding fumes		451: Interaction with lung resident cell membrane components leads to lung cancer
844	Wilson's disease		590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
682	WIN18,466		None
727	WIN18446		None
729	WIN18466		436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
470	Wnt		298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
479	Wnt ligand		None
471	WNT2		298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
472	WNT5A		None
523	Wntless		298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
668	Wood smoke		None
648	work stress		403: combined unhealthy lifestyle factors leading to metabolic syndrome
618	Wy-14,6423		None
411	Zampanolide		None
812	Zatebradine		2 AOPs 560: Inhibition of Funny current (If) leading to Arrhythmias 562: HCN Channel Inhibition leading to Arrhythmias
447	Zebularine		2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
723	Zinc	Zinc, CAS-RN: 7440-66-6, DTXSID7035012	615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
317	Zineb	Zineb, CAS-RN: 12122-67-7, DTXSID5021465	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity